Specifications
- Purity
- ≥98 (TLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in water (30mg/ml) or DMSO (10mg/ml).
- Melting Point
- 285 °C
Available from stock
Hexamethonium bromide
- SKU
- H0455
Category: Building Blocks, Intermediates, Reagents
- Synonyms
- N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dibromide, Hexane-1,6-bis(trimethylammonium bromide)
- 55-97-0
- CAS-Number
- C12H30Br2N2
- Molecular Formula
- 362.19
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- RT
- Long Term Storage
- RT
- Handling Advice
- Very hygroscopic. Store under inert gas.
- Use / Stability
- Stable for at least 2 years after receipt when stored at RT.
- Transportation
- Not dangerous goods
- Description
- Hexamethonium bromide is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs). Formulations containing hexamethonium were previously used in the treatment of hypertension. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation.
- Smiles
- C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
- InChi Key
- FAPSXSAPXXJTOU-UHFFFAOYSA-L
- References
- (1) A.R. Hunter, Lancet 1, 251 (1950) , (2) J.A. Gosling & T.C. Lu, J. Pharmacol. Exp. Ther. 167, 56 (1969) , (3) A.C. Villablanca, J. Appl. Physiol. 84, 2089 (1998) , (4) P. Dasgupta, et al., PNAS 103, 6332 (2010) , (5) Y. Nishida, et al., J. Physiol. Sci. 62, 147 (2012)
Hexamethonium bromide is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs). Formulations containing hexamethonium were previously used in the treatment of hypertension. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation.
Additional information
| Synonyms | N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dibromide, Hexane-1,6-bis(trimethylammonium bromide) |
|---|---|
| Purity | ≥98 (TLC) |
| Appearance | White to off-white powder |
| CAS-Number | 55-97-0 |
| Molecular Formula | C12H30Br2N2 |
| Molecular Weight | 362.19 |
| Identity | 1H-NMR |
| Solvents | Soluble in water (30mg/ml) or DMSO (10mg/ml). |
| Melting Point | 285 °C |
| Smiles | C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-] |
| InChi Key | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| Shipping | AMBIENT |
| Short Term Storage | RT |
| Long Term Storage | RT |
| Handling Advice | Very hygroscopic. Store under inert gas. |
| Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
| Transportation | Not dangerous goods |
| References | (1) A.R. Hunter, Lancet 1, 251 (1950), (2) J.A. Gosling & T.C. Lu, J. Pharmacol. Exp. Ther. 167, 56 (1969), (3) A.C. Villablanca, J. Appl. Physiol. 84, 2089 (1998), (4) P. Dasgupta, et al., PNAS 103, 6332 (2010), (5) Y. Nishida, et al., J. Physiol. Sci. 62, 147 (2012) |
| Quantity | 25 g, 100 g, Bulk |
