L-Alanyl-L-glutamine

SKU: A0222

Category: Amino Acids, Peptides, Proteins

Synonyms: H-Ala-Gln-OH , Ala-Gln , L-Ala L-Gln , Alanyl-glutamine , Glutamine-S; 39537-23-0
CAS-Number: C₈H₁₅N₃O₄
Molecular Formula: 217.22
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: water (20 mg/ml), ethanol (20mg/ml), DMSO and DMF (30mg/ml)

Short Term Storage: RT
Use / Stability: Stable for at least 2 years after receipt when stored at RT.
Handling Advice: Protect from light and moisture.
Long Term Storage: RT
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy. It improves pancreatic beta-cell function, maintaining the mitochondrial metabolism and stimulus-secretion coupling essential for insulin release.
References: (1) P.G. Boelens, et al., Am. J. Physiol. Endocrinol. Metab. 291, E683 (2006) , (2) Y. Imamoto, et al., Cytotechnology 65, 135 (2013) , (3) E.R. Petry, et al., Life Sci. 94, 130 (2014) , (4) V.F. Cruzat, et al., Nutrition 30, 602 (2014) , (5) M.V. Nova, et al., Drug Dev. Ind. Pharm. 40, 1308 (2014) , (6) G. Wang, et al., Ind. Eng. Chem. Res. 53, 3385 (2014) , (7) V.F. Cruzat, et al., J. Endocrinol. 224, 261 (2015)
InChi Key: HJCMDXDYPOUFDY-WHFBIAKZSA-N
Smiles: NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy. It improves pancreatic beta-cell function, maintaining the mitochondrial metabolism and stimulus-secretion coupling essential for insulin release.

SKU: A0222 Category: Amino Acids, Peptides, Proteins

Additional information

Additional information

Synonyms	H-Ala-Gln-OH, Ala-Gln, L-Ala L-Gln, Alanyl-glutamine, Glutamine-S
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	39537-23-0
Molecular Formula	C8H15N3O4
Molecular Weight	217.22
Identity	1H-NMR
Solvents	water (20 mg/ml), ethanol (20mg/ml), DMSO and DMF (30mg/ml)
Smiles	NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O
InChi Key	HJCMDXDYPOUFDY-WHFBIAKZSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	(1) P.G. Boelens, et al., Am. J. Physiol. Endocrinol. Metab. 291, E683 (2006), (2) Y. Imamoto, et al., Cytotechnology 65, 135 (2013), (3) E.R. Petry, et al., Life Sci. 94, 130 (2014), (4) V.F. Cruzat, et al., Nutrition 30, 602 (2014), (5) M.V. Nova, et al., Drug Dev. Ind. Pharm. 40, 1308 (2014), (6) G. Wang, et al., Ind. Eng. Chem. Res. 53, 3385 (2014), (7) V.F. Cruzat, et al., J. Endocrinol. 224, 261 (2015)
Quantity	10 g, 50 g, Bulk