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    L-Alanyl-L-glutamine

    Available from stock

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      L-Alanyl-L-glutamine

      SKU
      A0222

      Category: Amino Acids, Peptides, Proteins

      Synonyms
      H-Ala-Gln-OH , Ala-Gln , L-Ala L-Gln , Alanyl-glutamine , Glutamine-S
      39537-23-0
      CAS-Number
      C8H15N3O4
      Molecular Formula
      217.22
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Appearance
      White to off-white powder
      Identity
      1H-NMR

      Properties

      Solvents
      water (20 mg/ml), ethanol (20mg/ml), DMSO and DMF (30mg/ml)

      Documentation

      Safety Data Sheet (SDS)
      CDX A0222 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      RT
      Long Term Storage
      RT
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Transportation
      Not dangerous goods
      Description
      L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy. It improves pancreatic beta-cell function, maintaining the mitochondrial metabolism and stimulus-secretion coupling essential for insulin release.
      Smiles
      NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O
      InChi Key
      HJCMDXDYPOUFDY-WHFBIAKZSA-N
      References
      (1) P.G. Boelens, et al., Am. J. Physiol. Endocrinol. Metab. 291, E683 (2006) , (2) Y. Imamoto, et al., Cytotechnology 65, 135 (2013) , (3) E.R. Petry, et al., Life Sci. 94, 130 (2014) , (4) V.F. Cruzat, et al., Nutrition 30, 602 (2014) , (5) M.V. Nova, et al., Drug Dev. Ind. Pharm. 40, 1308 (2014) , (6) G. Wang, et al., Ind. Eng. Chem. Res. 53, 3385 (2014) , (7) V.F. Cruzat, et al., J. Endocrinol. 224, 261 (2015)

      L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy. It improves pancreatic beta-cell function, maintaining the mitochondrial metabolism and stimulus-secretion coupling essential for insulin release.

      SKU: A0222 Category: Amino Acids, Peptides, Proteins
      • Additional information

      Additional information

      Synonyms

      H-Ala-Gln-OH, Ala-Gln, L-Ala L-Gln, Alanyl-glutamine, Glutamine-S

      Purity

      ≥98% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      39537-23-0

      Molecular Formula

      C8H15N3O4

      Molecular Weight

      217.22

      Identity

      1H-NMR

      Solvents

      water (20 mg/ml), ethanol (20mg/ml), DMSO and DMF (30mg/ml)

      Smiles

      NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

      InChi Key

      HJCMDXDYPOUFDY-WHFBIAKZSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Transportation

      Not dangerous goods

      References

      (1) P.G. Boelens, et al., Am. J. Physiol. Endocrinol. Metab. 291, E683 (2006), (2) Y. Imamoto, et al., Cytotechnology 65, 135 (2013), (3) E.R. Petry, et al., Life Sci. 94, 130 (2014), (4) V.F. Cruzat, et al., Nutrition 30, 602 (2014), (5) M.V. Nova, et al., Drug Dev. Ind. Pharm. 40, 1308 (2014), (6) G. Wang, et al., Ind. Eng. Chem. Res. 53, 3385 (2014), (7) V.F. Cruzat, et al., J. Endocrinol. 224, 261 (2015)

      Quantity

      10 g, 50 g, Bulk

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