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    D-Aspartic acid

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    D-Aspartic acid

    SKU
    A0326

    Category: Amino Acids, Peptides, Proteins

    Synonyms
    (R)-(-)-Aminosuccinic acid , (R)-2-Aminosuccinic acid , D-Aminosuccinic acid , H-D-Asp-OH , D-Aspartate , D-Asp
    1783-96-6
    CAS-Number
    C4H7NO4
    Molecular Formula
    133.10
    Molecular Weight

    • Product Data
    • Handling
    • Safety Information
    • Details

    Specifications

    Purity
    ≥99% (Titration)
    Identity
    1H-NMR
    Appearance
    White to off-white powder

    Properties

    Optical Activity
    [α]20/D -24° to -26°, c = 2.3 in 6 M HCl
    Solvents
    water (slightly), 1N ammonium hydroxide (100 mg/ml)

    Downloads

    Safety Data Sheet
    CDX A0326 MSDS.pdf
    Short Term Storage
    RT
    Use / Stability
    Stable for at least 2 years after receipt when stored at RT.
    Handling Advice
    Protect from light and moisture.
    Long Term Storage
    RT
    Shipping
    AMBIENT
    Transportation
    Not dangerous goods
    Description
    Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.
    InChi
    InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
    References
    H.J. Olverman, et al., Neuroscience 26, 17 (1988) , S. Ishio, et al, Neurosci. Lett. 249, 143 (1998) , G. D'Aniello, et al., Endocrinol. 141, 3862 (2000) , A. D'Aniello, Brain Res. Rev. 53, 215 (2007) (Review) , E. Topo, et al., Reprod. Biol. Endocrinol. 7, 120 (2009) , E. Topo, et al., Amino Acids 38, 1561 (2010) , S. D'Aniello, et al., FASEB J. 25, 1014 (2011)
    InChi Key
    CKLJMWTZIZZHCS-UWTATZPHSA-N
    Smiles
    O=C(O)[C@H](N)CC(O)=O

    Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.

    SKU: A0326 Category: Amino Acids, Peptides, Proteins
    • Additional information

    Additional information

    Synonyms

    (R)-(-)-Aminosuccinic acid, (R)-2-Aminosuccinic acid, D-Aminosuccinic acid, H-D-Asp-OH, D-Aspartate, D-Asp

    Purity

    ≥99% (Titration)

    Appearance

    White to off-white powder

    CAS-Number

    1783-96-6

    Molecular Formula

    C4H7NO4

    Molecular Weight

    133.10

    Identity

    1H-NMR

    Solvents

    water (slightly), 1N ammonium hydroxide (100 mg/ml)

    Optical Activity

    [α]20/D -24° to -26°, c = 2.3 in 6 M HCl

    Smiles

    O=C(O)[C@H](N)CC(O)=O

    InChi Key

    CKLJMWTZIZZHCS-UWTATZPHSA-N

    Shipping

    AMBIENT

    Short Term Storage

    RT

    Long Term Storage

    RT

    Handling Advice

    Protect from light and moisture.

    Use / Stability

    Stable for at least 2 years after receipt when stored at RT.

    Transportation

    Not dangerous goods

    References

    H.J. Olverman, et al., Neuroscience 26, 17 (1988), S. Ishio, et al, Neurosci. Lett. 249, 143 (1998), G. D'Aniello, et al., Endocrinol. 141, 3862 (2000), A. D'Aniello, Brain Res. Rev. 53, 215 (2007) (Review), E. Topo, et al., Reprod. Biol. Endocrinol. 7, 120 (2009), E. Topo, et al., Amino Acids 38, 1561 (2010), S. D'Aniello, et al., FASEB J. 25, 1014 (2011)

    InChi

    InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1

    Quantity

    25 g, 100 g, Bulk

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