D-Aspartic acid

SKU: A0326

Category: Amino Acids, Peptides, Proteins

Synonyms: (R)-(-)-Aminosuccinic acid , (R)-2-Aminosuccinic acid , D-Aminosuccinic acid , H-D-Asp-OH , D-Aspartate , D-Asp; 1783-96-6
CAS-Number: C₄H₇NO₄
Molecular Formula: 133.10
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (Titration)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Optical Activity: [α]20/D -24° to -26°, c = 2.3 in 6 M HCl
Solvents: water (slightly), 1N ammonium hydroxide (100 mg/ml)

Short Term Storage: RT
Use / Stability: Stable for at least 2 years after receipt when stored at RT.
Handling Advice: Protect from light and moisture.
Long Term Storage: RT
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.
InChi: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
References: H.J. Olverman, et al., Neuroscience 26, 17 (1988) , S. Ishio, et al, Neurosci. Lett. 249, 143 (1998) , G. D'Aniello, et al., Endocrinol. 141, 3862 (2000) , A. D'Aniello, Brain Res. Rev. 53, 215 (2007) (Review) , E. Topo, et al., Reprod. Biol. Endocrinol. 7, 120 (2009) , E. Topo, et al., Amino Acids 38, 1561 (2010) , S. D'Aniello, et al., FASEB J. 25, 1014 (2011)
InChi Key: CKLJMWTZIZZHCS-UWTATZPHSA-N
Smiles: O=C(O)[C@H](N)CC(O)=O

Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.

SKU: A0326 Category: Amino Acids, Peptides, Proteins

Additional information

Additional information

Synonyms	(R)-(-)-Aminosuccinic acid, (R)-2-Aminosuccinic acid, D-Aminosuccinic acid, H-D-Asp-OH, D-Aspartate, D-Asp
Purity	≥99% (Titration)
Appearance	White to off-white powder
CAS-Number	1783-96-6
Molecular Formula	C4H7NO4
Molecular Weight	133.10
Identity	1H-NMR
Solvents	water (slightly), 1N ammonium hydroxide (100 mg/ml)
Optical Activity	[α]20/D -24° to -26°, c = 2.3 in 6 M HCl
Smiles	O=C(O)[C@H](N)CC(O)=O
InChi Key	CKLJMWTZIZZHCS-UWTATZPHSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	H.J. Olverman, et al., Neuroscience 26, 17 (1988), S. Ishio, et al, Neurosci. Lett. 249, 143 (1998), G. D'Aniello, et al., Endocrinol. 141, 3862 (2000), A. D'Aniello, Brain Res. Rev. 53, 215 (2007) (Review), E. Topo, et al., Reprod. Biol. Endocrinol. 7, 120 (2009), E. Topo, et al., Amino Acids 38, 1561 (2010), S. D'Aniello, et al., FASEB J. 25, 1014 (2011)
InChi	InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
Quantity	25 g, 100 g, Bulk