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    D-Aspartic acid

    Available from stock

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      D-Aspartic acid

      SKU
      A0326

      Category: Amino Acids, Peptides, Proteins

      Synonyms
      (R)-(-)-Aminosuccinic acid , (R)-2-Aminosuccinic acid , D-Aminosuccinic acid , H-D-Asp-OH , D-Aspartate , D-Asp
      1783-96-6
      CAS-Number
      C4H7NO4
      Molecular Formula
      133.10
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥99% (Titration)
      Identity
      1H-NMR
      Appearance
      White to off-white powder

      Properties

      Optical Activity
      [α]20/D -24° to -26°, c = 2.3 in 6 M HCl
      Solvents
      water (slightly), 1N ammonium hydroxide (100 mg/ml)

      Downloads

      Safety Data Sheet
      CDX A0326 MSDS.pdf
      Short Term Storage
      RT
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.
      InChi
      InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
      References
      H.J. Olverman, et al., Neuroscience 26, 17 (1988) , S. Ishio, et al, Neurosci. Lett. 249, 143 (1998) , G. D'Aniello, et al., Endocrinol. 141, 3862 (2000) , A. D'Aniello, Brain Res. Rev. 53, 215 (2007) (Review) , E. Topo, et al., Reprod. Biol. Endocrinol. 7, 120 (2009) , E. Topo, et al., Amino Acids 38, 1561 (2010) , S. D'Aniello, et al., FASEB J. 25, 1014 (2011)
      InChi Key
      CKLJMWTZIZZHCS-UWTATZPHSA-N
      Smiles
      O=C(O)[C@H](N)CC(O)=O

      Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone (GnRH) release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin (PRL), luteinizing hormone (LH) and growth hormone (GH). Also involved in testosterone and progesterone release.

      SKU: A0326 Category: Amino Acids, Peptides, Proteins
      • Additional information

      Additional information

      Synonyms

      (R)-(-)-Aminosuccinic acid, (R)-2-Aminosuccinic acid, D-Aminosuccinic acid, H-D-Asp-OH, D-Aspartate, D-Asp

      Purity

      ≥99% (Titration)

      Appearance

      White to off-white powder

      CAS-Number

      1783-96-6

      Molecular Formula

      C4H7NO4

      Molecular Weight

      133.10

      Identity

      1H-NMR

      Solvents

      water (slightly), 1N ammonium hydroxide (100 mg/ml)

      Optical Activity

      [α]20/D -24° to -26°, c = 2.3 in 6 M HCl

      Smiles

      O=C(O)[C@H](N)CC(O)=O

      InChi Key

      CKLJMWTZIZZHCS-UWTATZPHSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Transportation

      Not dangerous goods

      References

      H.J. Olverman, et al., Neuroscience 26, 17 (1988), S. Ishio, et al, Neurosci. Lett. 249, 143 (1998), G. D'Aniello, et al., Endocrinol. 141, 3862 (2000), A. D'Aniello, Brain Res. Rev. 53, 215 (2007) (Review), E. Topo, et al., Reprod. Biol. Endocrinol. 7, 120 (2009), E. Topo, et al., Amino Acids 38, 1561 (2010), S. D'Aniello, et al., FASEB J. 25, 1014 (2011)

      InChi

      InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1

      Quantity

      25 g, 100 g, Bulk

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