Available from stock

(+)-Naproxen methyl ester

SKU: N0557

Category: API's & Intermediates

Synonyms: (S)-Naproxen methyl ester, NME, Naproxen Impurity E (PhEur), (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester, Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoat; 26159-35-3
CAS-Number: C₁₅H₁₆O₃
Molecular Formula: 244.29
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder or crystals
Identity: 1H-NMR

Properties

Solvents: chloroform, methanol, DCM
Melting Point: 92.2 °C
Optical Activity: [α]/D 72.0 to 84.0°, c = 0.1 in chloroform

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H302 - H315 - H319 - H335 - H361fd - H411
Precautionary statements: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
GHS Symbol: GHS07+GHS08+GHS09
Signal word: Warning
RIDADR: UN3077
Transportation: Packing Group III

Description: The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.
Smiles: C(C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
InChi Key: ZFYFBPCRUQZGJE-UHFFFAOYSA-N
References: (1) M. Najlah, et al., Int. J. Pharm. 308, 175 (2006) , (2) H. Weber, et al., Arch. Pharm. 327, 337 (1994) , (3) C.J. Welch, et al., J. High Resol. Chromatogr. 20, 179 (1997) , (4) H. Weber, et al., Pharma. Res. 18, 600 (2001) , (5) J. Krzek & M. Starek, J. Plan. Chromatogr. 17, 137 (2004) , (6) L. Steenkamp & D. Brady, Proc. Biochem. 43, 1419 (2008) , (7) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010) , (8) R.S. Reddy, et al., TACL 6, 55 (2016) , (9) I. Cacciatore, et al., Int. J. Mol. Sci. 17, 1035 (2016) , (10) K. Birgul, et al., Eur. J. Med. Chem. 208, 112841 (2020)
InChi: InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3

The metabolite Naproxen methyl ester (Naproxen Impurity E) is a degradation product from Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) used to in the treatment of pain, menstrual cramps, inflammatory diseases such as rheumatoid arthritis, gout and fever. Ibuprofen is an anti-inflammatory COX inhibitor. This product can be used as a control esterase substrate, as a working standard or secondary analytical reference standard or as an organic building block and intermediate for synthesis.

SKU: N0557 Category: API's & Intermediates

Additional information

Additional information

Synonyms	(S)-Naproxen methyl ester, NME, Naproxen Impurity E (PhEur), (2S)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester, Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoat
Purity	≥98% (HPLC)
Appearance	White to off-white powder or crystals
CAS-Number	26159-35-3
Molecular Formula	C15H16O3
Molecular Weight	244.29
Identity	1H-NMR
Solvents	chloroform, methanol, DCM
Melting Point	92.2 °C
Optical Activity	[α]/D 72.0 to 84.0°, c = 0.1 in chloroform
Smiles	C(C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1
InChi Key	ZFYFBPCRUQZGJE-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H302 – H315 – H319 – H335 – H361fd – H411
Precautionary statements	P202 – P273 – P301 + P312 – P302 + P352 – P305 + P351 + P338 – P308 + P313
GHS Symbol	GHS07+GHS08+GHS09
Signal word	Warning
RIDADR	UN3077
Transportation	Packing Group III
References	(1) M. Najlah, et al., Int. J. Pharm. 308, 175 (2006), (2) H. Weber, et al., Arch. Pharm. 327, 337 (1994), (3) C.J. Welch, et al., J. High Resol. Chromatogr. 20, 179 (1997), (4) H. Weber, et al., Pharma. Res. 18, 600 (2001), (5) J. Krzek & M. Starek, J. Plan. Chromatogr. 17, 137 (2004), (6) L. Steenkamp & D. Brady, Proc. Biochem. 43, 1419 (2008), (7) K.C. Duggan, et al., J. Biol. Chem. 285, 34950 (2010), (8) R.S. Reddy, et al., TACL 6, 55 (2016), (9) I. Cacciatore, et al., Int. J. Mol. Sci. 17, 1035 (2016), (10) K. Birgul, et al., Eur. J. Med. Chem. 208, 112841 (2020)
InChi	InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3
Quantity	50 mg, Bulk