Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Solid
- Identity
- 1H-NMR
Properties
- Solvents
- acetone
- Fluorescence
- λex 300 nm, λem 416 nm in methanol (after derivatization with hexylamine)
Available from stock
Physil chloride
- SKU
- P0009
Categories: Fluorescent Detection, Fluorescent Detection
- Synonyms
- 4-(N-Phthalimidyl)-benzenesulfonyl chloride
- 114341-14-9
- CAS-Number
- C14H10ClNO3S
- Molecular Formula
- 307.75
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Hazard statements
- H315, H319, H335
- Precautionary statements
- P261, P305 + P351 + P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes (more than 1 ml) because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method. Phthalimidylbenzenesulfonyl chlorides habe also been successfully used for high sensitivity labelling of amino acids prior to HPLC.
- Smiles
- ClS(=O)(=O)C1=CC=C(C=C1)N1CC2=CC=CC=C2C1=O
- InChi Key
- PKWBLDDSBFCSPX-UHFFFAOYSA-N
- References
- (1) Y. Tsuruta et al.: Anal. Biochem. 243, 86 (1996) , (2) Y. Tsuruta et al.: J. Chromatogr. 502, 178 (1990) , (3) O.M. Bakke et al.: Toxicol. Appl. Pharmacol. 16, 691 (1970) , (4) C.N. Ong et al.: J. Chromatogr. 660, 1 (1959) , (5) R. Boutwell et al.: Cancer Res. 19, 413 (1959)
- InChi
- InChI=1S/C14H10ClNO3S/c15-20(18,19)12-7-5-11(6-8-12)16-9-10-3-1-2-4-13(10)14(16)17/h1-8H,9H2
It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes (more than 1 ml) because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method. Phthalimidylbenzenesulfonyl chlorides habe also been successfully used for high sensitivity labelling of amino acids prior to HPLC.
Additional information
| Synonyms | 4-(N-Phthalimidyl)-benzenesulfonyl chloride |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | Solid |
| CAS-Number | 114341-14-9 |
| Molecular Formula | C14H10ClNO3S |
| Molecular Weight | 307.75 |
| Identity | 1H-NMR |
| Solvents | acetone |
| Fluorescence | λex 300 nm, λem 416 nm in methanol (after derivatization with hexylamine) |
| Smiles | ClS(=O)(=O)C1=CC=C(C=C1)N1CC2=CC=CC=C2C1=O |
| InChi Key | PKWBLDDSBFCSPX-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H315, H319, H335 |
| Precautionary statements | P261, P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) Y. Tsuruta et al.: Anal. Biochem. 243, 86 (1996), (2) Y. Tsuruta et al.: J. Chromatogr. 502, 178 (1990), (3) O.M. Bakke et al.: Toxicol. Appl. Pharmacol. 16, 691 (1970), (4) C.N. Ong et al.: J. Chromatogr. 660, 1 (1959), (5) R. Boutwell et al.: Cancer Res. 19, 413 (1959) |
| InChi | InChI=1S/C14H10ClNO3S/c15-20(18,19)12-7-5-11(6-8-12)16-9-10-3-1-2-4-13(10)14(16)17/h1-8H,9H2 |
| Quantity | 50 mg, 250 mg, Bulk |
