Available from stock

Procyanidin B2

SKU: P0591

Category: Phytochemicals

Synonyms: (−)-Epicatechin (4β-8)-(−)-epicatechin, 4,8″-Bi-[(+)-epicatechin], cis,cis″-4,8″-Bi-(3,3′,4′,5,7-pentahydroxy-flavan), Proanthocyanidin B2, Procy; 29106-49-8
CAS-Number: C₃₀H₂₆O₁₂
Molecular Formula: 578.52
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥90% (HPLC)
Appearance: Light beige/brown to beige/brown powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO, ethanol, DMF (all 30mg/ml) or water (10mg/ml).
Melting Point: 197-198° C
Refractive Index: 1.80 (Predicted)
Density: 1.71 g/cm3

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Transportation: Not dangerous goods

Description: Procyanidin B2, one of the most representative naturally occurring edible pigments, is usually isolated from the seeds, fruits and leaves of lots of common plants, such as grapes or apples. Procyanidin B2 has numerous bioactivities, including anti-inflammatory, anti-oxidative stress, neuroprotective, lipid metabolism regulating, wound healing, anti-diabetic, metabolic syndrome regulating, anti-atherosclerotic, anti-adipogenesis, anti-viral and anti-cancer properties. Procyanidin B2 targets and mediates several signaling pathways like NF-&kappa,B, MAPK, PI3K/Akt, NLRP3, apoptotic axis, VEGF/VEGFR2, PPAR&gamma, and Nrf-2/HO-1. Procyanidin B2 possesses the potential to treat/prevent a wide range of human diseases, such as diabetes mellitus, diabetic complications, atherosclerosis, cancers and non-alcoholic fatty liver disease.
Smiles: O[C@@H]1[C@@H](C2=C3C(C[C@@H](O)[C@@H](C4=CC(O)=C(O)C=C4)O3)=C(O)C=C2O)C5=C(O)C=C(O)C=C5O[C@@H]1C6=CC(O)=C(O)C=C6
InChi Key: XFZJEEAOWLFHDH-NFJBMHMQSA-N
References: (1) M.M. Avelar & C.M.C.P. Gouvea, Indian J. Pharm. Sci. 74, 351 (2012) , (2) H. Yang, et al., Biochem. Pharmacol. 92, 599 (2014) , (3) T.C. Sutcliffe, et al., Antioxidants 6, 77 (2017) , (4) S. Gopalakrishnan, et al., IUBMB Life 70, 445 (2018) , (5) J. Feng, et al., J. Cell. Mol. Med. 23, 6479 (2019) , (6) Y. Tian, et al., Front. Immunol. 10, 1895 (2019) , (7) X. Zhu, et al., Antioxid. Redox Signal. 35, 75 (2021) , (8) L. Liu, et al., Pharmacol. Res. 177, 106127 (2022) , (9) M. Xu, et al., Anim. Biotechnol. 33, 346 (2022) , (10) Q. Sun, et al., Bioengineered 13, 6500 (2022) , (11) J. Liu, et al., Nutrients 14, 1756 (2022) , (12) J. Zhao, et al., Cell Death Dis. 13, 594 (2022) , (13) H. Wang, et al., Int. J. Mol. Sci. 23, 7769 (2022) , (14) W. Cai, et al., Int. Immunopharmacol. 113, 109336 (2022) , (15) Y.P. Zou, et al., J. Orthop. Res. 41, 1555 (2023) , J. Chen, et al., Food Chem. 420, 136101 (2023)

Procyanidin B2, one of the most representative naturally occurring edible pigments, is usually isolated from the seeds, fruits and leaves of lots of common plants, such as grapes or apples. Procyanidin B2 has numerous bioactivities, including anti-inflammatory, anti-oxidative stress, neuroprotective, lipid metabolism regulating, wound healing, anti-diabetic, metabolic syndrome regulating, anti-atherosclerotic, anti-adipogenesis, anti-viral and anti-cancer properties. Procyanidin B2 targets and mediates several signaling pathways like NF-&kappa,B, MAPK, PI3K/Akt, NLRP3, apoptotic axis, VEGF/VEGFR2, PPAR&gamma, and Nrf-2/HO-1. Procyanidin B2 possesses the potential to treat/prevent a wide range of human diseases, such as diabetes mellitus, diabetic complications, atherosclerosis, cancers and non-alcoholic fatty liver disease.

SKU: P0591 Category: Phytochemicals

Additional information

Additional information

Synonyms	(−)-Epicatechin (4β-8)-(−)-epicatechin, 4,8″-Bi-[(+)-epicatechin], cis,cis″-4,8″-Bi-(3,3′,4′,5,7-pentahydroxy-flavan), Proanthocyanidin B2, Procy
Purity	≥90% (HPLC)
Appearance	Light beige/brown to beige/brown powder
CAS-Number	29106-49-8
Molecular Formula	C30H26O12
Molecular Weight	578.52
Identity	1H-NMR
Solvents	Soluble in DMSO, ethanol, DMF (all 30mg/ml) or water (10mg/ml).
Melting Point	197-198° C
Refractive Index	1.80 (Predicted)
Density	1.71 g/cm3
Smiles	O[C@@H]1[C@@H](C2=C3C(C[C@@H](O)[C@@H](C4=CC(O)=C(O)C=C4)O3)=C(O)C=C2O)C5=C(O)C=C(O)C=C5O[C@@H]1C6=CC(O)=C(O)C=C6
InChi Key	XFZJEEAOWLFHDH-NFJBMHMQSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) M.M. Avelar & C.M.C.P. Gouvea, Indian J. Pharm. Sci. 74, 351 (2012), (2) H. Yang, et al., Biochem. Pharmacol. 92, 599 (2014), (3) T.C. Sutcliffe, et al., Antioxidants 6, 77 (2017), (4) S. Gopalakrishnan, et al., IUBMB Life 70, 445 (2018), (5) J. Feng, et al., J. Cell. Mol. Med. 23, 6479 (2019), (6) Y. Tian, et al., Front. Immunol. 10, 1895 (2019), (7) X. Zhu, et al., Antioxid. Redox Signal. 35, 75 (2021), (8) L. Liu, et al., Pharmacol. Res. 177, 106127 (2022), (9) M. Xu, et al., Anim. Biotechnol. 33, 346 (2022), (10) Q. Sun, et al., Bioengineered 13, 6500 (2022), (11) J. Liu, et al., Nutrients 14, 1756 (2022), (12) J. Zhao, et al., Cell Death Dis. 13, 594 (2022), (13) H. Wang, et al., Int. J. Mol. Sci. 23, 7769 (2022), (14) W. Cai, et al., Int. Immunopharmacol. 113, 109336 (2022), (15) Y.P. Zou, et al., J. Orthop. Res. 41, 1555 (2023), J. Chen, et al., Food Chem. 420, 136101 (2023)
Quantity	1 mg, Bulk