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    Rhod-2 AM

    Available from stock

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      Rhod-2 AM

      SKU
      A0072

      Categories: Fluorescent Detection, Fluorescent Detection

      Synonyms
      129787-64-0
      145037-81-6
      CAS-Number
      C52H59BrN4O19
      Molecular Formula
      1123.96
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥80% (HPLC)
      Appearance
      Red-purple solid

      Properties

      Solvents
      DMSO, DMF, methanol, chloroform

      Documentation

      Safety Data Sheet (SDS)
      CDX A0072 MSDS.pdf
      Shipping
      AMBIENT
      Short Term Storage
      -20°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Transportation
      Not dangerous goods
      Description
      Long-wavelength cell-permeant Ca2+ indicator. Rhod-2/AM is an acetoxymethyl ester derivative of Rhod 2 that can be easily loaded into cells via incubation and used for quantifying intracellular Ca2+ concentration allowing non-invasive measurement of calcium ions in live cells. This fluoregenic probe for intracellular Ca2+ operates in the visible spectrum. Rhod-2/AM itself does not bind Ca2+, but it is readily hydrolyzed to Rhod-2 by endogenous esterases once the dye enters cells. Rhod-2 is a valuable alternative to Fluo-3 to investigate changes in intracellular free Ca2+ concentrations, especially in cells and tissues that have high levels of autofluorescence. Rhod-2 has the longest fluorescent emission signal of the commonly used calcium indicators. It contains a rhodamine-like fluorophore, whose excitation and emission maxima make it suitable for use with argon and krypton laser. Its signal intensity is the strongest of all the calcium probes. Spectral Data: ?ex 550nm, ?em 578nm in methanol, λex 549nm, λem 578nm in DMSO, λex 550nm, λem 570nm in Chloroform, Methanol (90:10)
      Smiles
      O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=C(C=C(C=C1)C2=C3C=C/C(C=C3OC4=CC(N(C)C)=CC=C24)=[N+](C)/C)OCCOC5=C(C=CC(C)=C5)N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O.[Br-]
      InChi Key
      RWXWZOWDWYQKBK-UHFFFAOYSA-M
      References
      (1) A. Minta, et al., J. Biol. Chem. 264, 8171 (1989) , (2) T.M. Quinton, et al., BBRC 184, 893 (1992) , (3) M. Okada, et al., Brain Res. 583, 227 (1992) , (4) Y. Tamura, et al., Brain Res. 592, 317 (1992) , (5) N. Melamed, et al., J. Neurosci. 13, 632 (1993) , (6) C. Du, et al., Biophys. J. 80, 549 (2001) , (7) Y.N. Tallini, et al., PNAS 103, 4753 (2006) , (8) P.R. Territo, et al., Appl. Spectrosc. 61, 138 (2007) , (9) B.R. Choi, Methods Mol. Biol. 937, 217 (2013)
      InChi
      InChI=1S/C52H59N4O19.BrH/c1-32-10-16-42(55(24-48(61)71-28-67-33(2)57)25-49(62)72-29-68-34(3)58)46(20-32)65-18-19-66-47-21-37(11-17-43(47)56(26-50(63)73-30-69-35(4)59)27-51(64)74-31-70-36(5)60)52-40-14-12-38(53(6)7)22-44(40)75-45-23-39(54(8)9)13-15-41(45)52,/h10-17,20-23H,18-19,24-31H2,1-9H3,1H/q+1,/p-1

      Long-wavelength cell-permeant Ca2+ indicator. Rhod-2/AM is an acetoxymethyl ester derivative of Rhod 2 that can be easily loaded into cells via incubation and used for quantifying intracellular Ca2+ concentration allowing non-invasive measurement of calcium ions in live cells. This fluoregenic probe for intracellular Ca2+ operates in the visible spectrum. Rhod-2/AM itself does not bind Ca2+, but it is readily hydrolyzed to Rhod-2 by endogenous esterases once the dye enters cells. Rhod-2 is a valuable alternative to Fluo-3 to investigate changes in intracellular free Ca2+ concentrations, especially in cells and tissues that have high levels of autofluorescence. Rhod-2 has the longest fluorescent emission signal of the commonly used calcium indicators. It contains a rhodamine-like fluorophore, whose excitation and emission maxima make it suitable for use with argon and krypton laser. Its signal intensity is the strongest of all the calcium probes. Spectral Data: ?ex 550nm, ?em 578nm in methanol, λex 549nm, λem 578nm in DMSO, λex 550nm, λem 570nm in Chloroform, Methanol (90:10)

      SKU: A0072 Categories: Fluorescent Detection, Fluorescent Detection
      • Additional information

      Additional information

      Synonyms

      129787-64-0

      Purity

      ≥80% (HPLC)

      Appearance

      Red-purple solid

      CAS-Number

      145037-81-6

      Molecular Formula

      C52H59BrN4O19

      Molecular Weight

      1123.96

      Solvents

      DMSO, DMF, methanol, chloroform

      Smiles

      O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=C(C=C(C=C1)C2=C3C=C/C(C=C3OC4=CC(N(C)C)=CC=C24)=[N+](C)/C)OCCOC5=C(C=CC(C)=C5)N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O.[Br-]

      InChi Key

      RWXWZOWDWYQKBK-UHFFFAOYSA-M

      Shipping

      AMBIENT

      Short Term Storage

      -20°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) A. Minta, et al., J. Biol. Chem. 264, 8171 (1989), (2) T.M. Quinton, et al., BBRC 184, 893 (1992), (3) M. Okada, et al., Brain Res. 583, 227 (1992), (4) Y. Tamura, et al., Brain Res. 592, 317 (1992), (5) N. Melamed, et al., J. Neurosci. 13, 632 (1993), (6) C. Du, et al., Biophys. J. 80, 549 (2001), (7) Y.N. Tallini, et al., PNAS 103, 4753 (2006), (8) P.R. Territo, et al., Appl. Spectrosc. 61, 138 (2007), (9) B.R. Choi, Methods Mol. Biol. 937, 217 (2013)

      InChi

      InChI=1S/C52H59N4O19.BrH/c1-32-10-16-42(55(24-48(61)71-28-67-33(2)57)25-49(62)72-29-68-34(3)58)46(20-32)65-18-19-66-47-21-37(11-17-43(47)56(26-50(63)73-30-69-35(4)59)27-51(64)74-31-70-36(5)60)52-40-14-12-38(53(6)7)22-44(40)75-45-23-39(54(8)9)13-15-41(45)52,/h10-17,20-23H,18-19,24-31H2,1-9H3,1H/q+1,/p-1

      Quantity

      1 mg, Bulk

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