TFMU

Specifications

Purity

≥98% (NMR)

Identity

1H-NMR

Appearance

White to off-white crystalline powder

Properties

Other

pKa: 7.26

Fluorescence

λex 355 nm, λem 498 nm in 0.1 M citrate pH 3.0

Melting Point

178-180°C

Solvents

alcohols, DMSO or DMF

Downloads

Safety Data Sheet

CDX T0003 MSDS.pdf

Long Term Storage

+4°C

Use / Stability

Stable for at least 2 years after receipt when stored at +4°C.

Handling Advice

Protect from light and moisture.

Short Term Storage

+4°C

Shipping

AMBIENT

Transportation

Excepted Quantities

RIDADR

UN2811 6.1

Signal word

Danger

GHS Symbol

GHS06

Precautionary statements

P261, P264, P301 + P310, P305 + P351 + P338

Hazard statements

H300, H315, H319, H335

Description

This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.

InChi

InChI=1S/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H

References

(1) P. Baranczewski: Assay and Drug Developm. Techn. 2(4), 345 (2004) , (2) A.B. Renwick: Xenobiotica 30(10), 955 (2000) , (3) G. Luyten et al.: J. Histochem. Cytochem. 33, 965 (1985)

InChi Key

CCKWMCUOHJAVOL-UHFFFAOYSA-N

Smiles

OC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1