Specifications
- Purity
- ≥95% (HPLC)
- Appearance
- Yellow to brown powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10mg/ml), DMF (20 mg/ml)
Category: Phytochemicals
Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression.
Synonyms | Chamomile, Flavone, NSC 83244, Versulin, 4',5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone |
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Purity | ≥95% (HPLC) |
Appearance | Yellow to brown powder |
CAS-Number | 520-36-5 |
Molecular Formula | C15H10O5 |
Molecular Weight | 270.24 |
Identity | 1H-NMR |
Solvents | DMSO (10mg/ml), DMF (20 mg/ml) |
Smiles | OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1 |
InChi Key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) Y.C. Liang, et al., Carcinogenesis 20, 1945 (1999), (2) D.H. Song, et al., J. Biol. Chem. 275, 23790 (2000), (3) J. Shen, et al., J. Immunol. 167, 4919 (2001), (4) G.M. Raso, et al., Life Sci. 68, 921 (2001), (5) M. Yamada, et al., PNAS 102, 7736 (2005), (6) M.B. Ujiki, et al., Mol. Cancer 5, 76 (2006), (7) J. Fang, et al., Carcinogenesis 28, 858 (2006), (8) X. Yan, et al., Cell Biosci. 7, 50 (2017) (Review), (9) S.F. Nabavi, et al., Pharmacol. Res. 128, 359 (2018) (Review), (10) J. Madunic, et al., Cancer Lett. 413, 11 (2018) (Review) |
Quantity | 25 mg, 100 mg, Bulk |