Specifications
- Purity
- ≥95% (HPLC)
- Appearance
- Brown powder
- Identity
- 1H-NMR
Properties
- Solvents
- ethanol (slightly), DMSO (<1 mg/ml)
Category: Phytochemicals
Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark and peels. It has antioxidant, anticancer, neuroprotective, antimutagenic, anti-inflammatory and organ-preserving properties. It alters cytochrome P450 activity and improvea metabolism and clearance of xenobiotics, as well as altera immune function. Selective, ATP-competitive inhibitor of casein kinase 2 (CK2). Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity. It acts as a scavenger of oxygen species produced by hydrogen peroxide treatment and as a protector of the DNA double helix from alkylating agent injury. Also reported to inhibit topoisomerases I and II and gyrase and glutathione S-transferase.
Synonyms | 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Gallogen, Lagistase, TBBD |
---|---|
Purity | ≥95% (HPLC) |
Appearance | Brown powder |
CAS-Number | 476-66-4 |
Molecular Formula | C14H6O8 |
Molecular Weight | 302.19 |
Identity | 1H-NMR |
Solvents | ethanol (slightly), DMSO (<1 mg/ml) |
Smiles | OC1=CC2=C3C(OC(C4=C3C(OC2=O)=C(O)C(O)=C4)=O)=C1O |
InChi Key | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) C.T. Allen, et al., Immunopharmacol. Immunotoxicol. 25, 409 (2003), (2) G. Cozza, et al., J. Med. Chem. 49, 2363 (2006), (3) D.H. Han, et al., Anticancer Res. 26, 3601 (2006), (4) R. Hayeshi, et al., Food Chem. Toxicol. 45, 286 (2007), (5) D. Heber, Cancer Lett. 269, 262 (2008), (6) C. Bell & S. Hawthorne, J. Pharm. Pharmacol. 60, 139 (2008) (Review), (7) B.R. Selvi, et al., J. Biol. Chem. 285, 7143 (2010), (8) J. Paluszczak, et al., Toxicol. Lett. 192, 119 (2010), (9) M.A. Lea, et al., Anticancer Res. 30, 311 (2010), (10) H.M. Zhang, et al., Cancer Biol. Med. 11, 92 (2014) (Review), (11) W.R. García-Nino & C. Zazueta, Pharmacol. Res. 97, 84 (2015) (Review), (12) T. Ahmed, et al., Curr. Pharm. Des. 22, 1350 (2016) (Review), (13) G. Derosa, et al., Adv. Exp. Med. Biol. 928, 4473 (Review), (14) A. Zeb, Mol. Cell Biochem. 448, 27 (2018) (Review), (15) C. Ceci, et al., Nutrients 10, E1756 (2018), (16) S. Alfei, et al., Eur. J. Med. Chem. 183, 111724 (2019) (Review) |
InChi | InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H |
Quantity | 1 g, 5 g, 10 g, Bulk |