Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- White to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO or DMF (both 10 mg/ml), ethanol (slightly), methanol or water (1 mg/ml)
Category: API's & Intermediates
Micafungin is a semisynthetic echinocandin antifungal. Micafungin inhibits the enzyme β(1,3)-D-Glucan synthase, consequently 1,3-β-D-glucan synthesis and thereby disturbing the integrity of the fungal cell wall. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp. The target enzyme does not exist in mammalian systems.
Synonyms | Mycamine, Funguard, FK463, 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 sodium salt |
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Purity | ≥97% (HPLC) |
Appearance | White to beige powder |
CAS-Number | 208538-73-2 |
Molecular Formula | C56H70N9NaO23S |
Molecular Weight | 1292.26 |
Identity | 1H-NMR |
Solvents | DMSO or DMF (both 10 mg/ml), ethanol (slightly), methanol or water (1 mg/ml) |
Smiles | O[C@@H]([C@@H](C)C1)[C@@H](C(N[C@@H]([C@@H](C2)O)O)=O)N1C([C@H]([C@@H](CC(N)=O)O)NC([C@H]([C@@H]([C@H](C(C=C3)=CC(OS([O-])(=O)=O)=C3O)O)O)NC([C@H](C[C@H]4O)N(C4)C([C@H]([C@@H](C)O)NC([C@H]2NC(C(C=C5)=CC=C5C6=NOC(C(C=C7)=CC=C7OCCCCC)=C6)=O)=O)=O)=O)=O)=O.[ |
InChi Key | KOOAFHGJVIVFMZ-WZPXRXMFSA-M |
Shipping | BLUE ICE |
Short Term Storage | -20°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) M. Tomishima, et al., J. Antibiot. 52, 674 (1999), (2) R.A. Fromtling, Drugs Today 38, 245 (2002) (Review), (3) A.J. Carillo-Muñoz, et al., Rev. Esp. Quimioter. 19, 130 (2006), (4) J.J. Vehreschild & O.A. Cornely, Future Microbiol. 1, 161 (2006), (5) J.M. Joseph, et al., Pharmacotherapy 27, 53 (2007) (Review), (6) N.P. Wiederhold & J.S. Lewis, Expert Opin. Pharmacother. 8, 1155 (2007) (Review), (7) A.M. Bormann & V.A. Morrison, Drug. Des. Devel. Ther. 3, 295 (2009) |
Quantity | 5 mg, 25 mg, Bulk |