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    Bimatoprost

    Available from stock

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      Bimatoprost

      SKU
      P0325

      Category: Lipids, Fatty Acids

      Synonyms
      17-Phenyl-tri-norprostaglandin F2α-ethyl amide , cGMP Bimatoprost , AGN-192024 , Lumigan , Prostamide
      155206-00-1
      CAS-Number
      C25H37NO4
      Molecular Formula
      415.57
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥95% (HPLC)
      Appearance
      White to off-white powder
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Transportation
      Not dangerous goods
      Description
      Bimatoprost is a synthetic prostamide FP receptor agonist, structurally related to prostaglandin F2α that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. Bimatoprost is therefore an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
      Smiles
      O[C@H]1C[C@@H](O)[C@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H]1C/C=CCCCC(NCC)=O
      InChi Key
      AQOKCDNYWBIDND-FTOWTWDKSA-N
      References
      (1) L.B. Cantor, et al., Expert Opin. Investig. Drugs 10, 721 (2001) (Review) , (2) R.F. Brubaker, Surv. Ophthalmol. 45, S347 (2001) (Review) , (3) A.H. Krauss & D.F. Woodward, Surv. Ophthalmol. 49, S5 (2004) (Review) , (4) D.F. Woodward, et al., Cardiovasc. Drug Rev. 22, 103 (2004) (Review)
      InChi
      InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1

      Bimatoprost is a synthetic prostamide FP receptor agonist, structurally related to prostaglandin F2α that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. Bimatoprost is therefore an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

      SKU: P0325 Category: Lipids, Fatty Acids
      • Additional information

      Additional information

      Synonyms

      17-Phenyl-tri-norprostaglandin F2α-ethyl amide, cGMP Bimatoprost, AGN-192024, Lumigan, Prostamide

      Purity

      ≥95% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      155206-00-1

      Molecular Formula

      C25H37NO4

      Molecular Weight

      415.57

      Identity

      1H-NMR

      Solvents

      DMSO

      Smiles

      O[C@H]1C[C@@H](O)[C@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H]1C/C=CCCCC(NCC)=O

      InChi Key

      AQOKCDNYWBIDND-FTOWTWDKSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      (1) L.B. Cantor, et al., Expert Opin. Investig. Drugs 10, 721 (2001) (Review), (2) R.F. Brubaker, Surv. Ophthalmol. 45, S347 (2001) (Review), (3) A.H. Krauss & D.F. Woodward, Surv. Ophthalmol. 49, S5 (2004) (Review), (4) D.F. Woodward, et al., Cardiovasc. Drug Rev. 22, 103 (2004) (Review)

      InChi

      InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1

      Quantity

      1 mg, 5 mg, Bulk

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