Bimatoprost

SKU: P0325

Category: Lipids, Fatty Acids

Synonyms: 17-Phenyl-tri-norprostaglandin F2α-ethyl amide , cGMP Bimatoprost , AGN-192024 , Lumigan , Prostamide; 155206-00-1
CAS-Number: C₂₅H₃₇NO₄
Molecular Formula: 415.57
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (HPLC)
Identity: 1H-NMR
Appearance: White to off-white powder

Properties

Solvents: DMSO

Short Term Storage: +4°C
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: -20°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Bimatoprost is a synthetic prostamide FP receptor agonist, structurally related to prostaglandin F2α that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. Bimatoprost is therefore an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
InChi: InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
References: (1) L.B. Cantor, et al., Expert Opin. Investig. Drugs 10, 721 (2001) (Review) , (2) R.F. Brubaker, Surv. Ophthalmol. 45, S347 (2001) (Review) , (3) A.H. Krauss & D.F. Woodward, Surv. Ophthalmol. 49, S5 (2004) (Review) , (4) D.F. Woodward, et al., Cardiovasc. Drug Rev. 22, 103 (2004) (Review)
InChi Key: AQOKCDNYWBIDND-FTOWTWDKSA-N
Smiles: O[C@H]1C[C@@H](O)[C@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H]1C/C=CCCCC(NCC)=O

Bimatoprost is a synthetic prostamide FP receptor agonist, structurally related to prostaglandin F2α that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma. Bimatoprost is therefore an antiglaucoma agent. Bimatoprost is converted by an amidase enzymatic activity to yield the corresponding free acid, 17-phenyl trinor PGF2α, a potent PGF2αR agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

SKU: P0325 Category: Lipids, Fatty Acids

Additional information

Additional information

Synonyms	17-Phenyl-tri-norprostaglandin F2α-ethyl amide, cGMP Bimatoprost, AGN-192024, Lumigan, Prostamide
Purity	≥95% (HPLC)
Appearance	White to off-white powder
CAS-Number	155206-00-1
Molecular Formula	C25H37NO4
Molecular Weight	415.57
Identity	1H-NMR
Solvents	DMSO
Smiles	O[C@H]1C[C@@H](O)[C@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H]1C/C=CCCCC(NCC)=O
InChi Key	AQOKCDNYWBIDND-FTOWTWDKSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) L.B. Cantor, et al., Expert Opin. Investig. Drugs 10, 721 (2001) (Review), (2) R.F. Brubaker, Surv. Ophthalmol. 45, S347 (2001) (Review), (3) A.H. Krauss & D.F. Woodward, Surv. Ophthalmol. 49, S5 (2004) (Review), (4) D.F. Woodward, et al., Cardiovasc. Drug Rev. 22, 103 (2004) (Review)
InChi	InChI=1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
Quantity	1 mg, 5 mg, Bulk