Specifications
- Purity
- ≥97% (NMR)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (10 mg/ml)
- Melting Point
- 115-119°C
Documentation
- Safety Data Sheet (SDS)
- CDX O0041 MSDS.pdf
Available from stock
Omeprazole sulfide
- SKU
- O0041
Category: API's & Intermediates
- Synonyms
- Omeprazole impurity C (PhEur) , Pyrmetazol , Ufiprazole
- 73590-85-9
- CAS-Number
- C17H19N3O2S
- Molecular Formula
- 329.42
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305 + P351 + P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Omeprazole sulfide is an aryl hydrocarbon receptor (AhR) antagonist. Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole. Omeprazole sulfide is also a degradation product (Omeprazole Impurity C) of Omperazole, and it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes. Omeprazole is a selective and irreversible proton pump inhibitor. It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production. Omeprazole sulfide can be usd as reference material.
- Smiles
- CC(C(OC)=C(C)C=N1)=C1CSC2=NC3=CC(OC)=CC=C3N2
- InChi Key
- XURCIPRUUASYLR-UHFFFAOYSA-N
- References
- (1) S. Gerbal-Chaloin, et al., Cell Signal. 18, 740 (2006) , (2) B.W. Ogilvie, e al., Drug Metab. Dispos. 39, 2020 (2011) , (3) L. Olbe, et al., Nat. Rev. Drug Discovery 2, 132 (2003) (Review)
- InChi
- InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
Omeprazole sulfide is an aryl hydrocarbon receptor (AhR) antagonist. Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole. Omeprazole sulfide is also a degradation product (Omeprazole Impurity C) of Omperazole, and it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes. Omeprazole is a selective and irreversible proton pump inhibitor. It suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the final step of acid production. Omeprazole sulfide can be usd as reference material.
Additional information
| Synonyms | Omeprazole impurity C (PhEur), Pyrmetazol, Ufiprazole |
|---|---|
| Purity | ≥97% (NMR) |
| Appearance | White to off-white powder |
| CAS-Number | 73590-85-9 |
| Molecular Formula | C17H19N3O2S |
| Molecular Weight | 329.42 |
| Identity | 1H-NMR |
| Solvents | DMSO (10 mg/ml), DMF (10 mg/ml), ethanol (10 mg/ml) |
| Melting Point | 115-119°C |
| Smiles | CC(C(OC)=C(C)C=N1)=C1CSC2=NC3=CC(OC)=CC=C3N2 |
| InChi Key | XURCIPRUUASYLR-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) S. Gerbal-Chaloin, et al., Cell Signal. 18, 740 (2006), (2) B.W. Ogilvie, e al., Drug Metab. Dispos. 39, 2020 (2011), (3) L. Olbe, et al., Nat. Rev. Drug Discovery 2, 132 (2003) (Review) |
| InChi | InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20) |
| Quantity | 25 mg, 50 mg, Bulk |
