Available from stock

Caspofungin diacetate

SKU: C0267

Category: Antibiotics

Synonyms: L-743,872 , MK 0991; 179463-17-3
CAS-Number: C₅₂H₈₈N₁₀O₁₅ · ₂C₂H₄O₂
Molecular Formula: 1213.42
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to beige powder
Identity: 1H-NMR

Properties

Solvents: DMSO (25 mg/ml), DMF (20 mg/ml), ehtanol (20 mg/ml), water (15 mg/ml)

Documentation

Safety Data Sheet (SDS): CDX C0267 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Caspofungin acetate is an antifungal compound that is classified as an echinocandin. It is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by non-competititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan and distutbing the integrity in the fungal cell wall. This agent is used in fungal cell wall biosynthesis research to study the role of β-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. It is effective against disseminated or invasive aspergillosis and candidiasis in mice.
Smiles: OC(C)=O.O=C([C@H]([C@@H](CCN)O)NC([C@H]([C@@H]([C@H](C(C=C1)=CC=C1O)O)O)NC([C@H](C2)N(C[C@@H]2O)C([C@H]([C@@H](C)O)NC([C@@H](NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)C3)=O)=O)=O)=O)N4[C@@](C(N[C@@H]([C@@H]3O)NCCN)=O)([H])[C@@H](O)CC4.O=C(C)O
InChi Key: OGUJBRYAAJYXQP-IJFZAWIJSA-N
References: (1) G.K. Abruzzo, et al., Antimicrob. Agents Chemother. 41, 2333 (1997) , (2) V. Letscher-Bru, et al., J. Antimicrob. Chemother. 51, 513 (2003) , (3) S.C. Deresinski & D.A. Stevens, Clin. Infect. Dis. 36, 1445 (2003) , (4) R. Herbrecht, et al., J. Antimicrob. Chemother. 56, i39 (2005) , (5) M.A. Pfaller, et al., J. Clin. Microbiol. 47, 3323 (2009) , (6) J.M. Balkovec, et al., Nat. Prod. Rep. 31, 15 (2014)
InChi: InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72,2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75),2*1H3,(H,3,4)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-,,/m0../s1

Caspofungin acetate is an antifungal compound that is classified as an echinocandin. It is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by non-competititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan and distutbing the integrity in the fungal cell wall. This agent is used in fungal cell wall biosynthesis research to study the role of β-1,3-D-glucans in cell wall integrity and fungal survival under various environmental and chemical stresses. It is effective against disseminated or invasive aspergillosis and candidiasis in mice.

SKU: C0267 Category: Antibiotics

Additional information

Additional information

Synonyms	L-743,872, MK 0991
Purity	≥98% (HPLC)
Appearance	White to beige powder
CAS-Number	179463-17-3
Molecular Formula	C52H88N10O15 · 2C2H4O2
Molecular Weight	1213.42
Identity	1H-NMR
Solvents	DMSO (25 mg/ml), DMF (20 mg/ml), ehtanol (20 mg/ml), water (15 mg/ml)
Smiles	OC(C)=O.O=C([C@H]([C@@H](CCN)O)NC([C@H]([C@@H]([C@H](C(C=C1)=CC=C1O)O)O)NC([C@H](C2)N(C[C@@H]2O)C([C@H]([C@@H](C)O)NC([C@@H](NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)C3)=O)=O)=O)=O)N4[C@@](C(N[C@@H]([C@@H]3O)NCCN)=O)([H])[C@@H](O)CC4.O=C(C)O
InChi Key	OGUJBRYAAJYXQP-IJFZAWIJSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) G.K. Abruzzo, et al., Antimicrob. Agents Chemother. 41, 2333 (1997), (2) V. Letscher-Bru, et al., J. Antimicrob. Chemother. 51, 513 (2003), (3) S.C. Deresinski & D.A. Stevens, Clin. Infect. Dis. 36, 1445 (2003), (4) R. Herbrecht, et al., J. Antimicrob. Chemother. 56, i39 (2005), (5) M.A. Pfaller, et al., J. Clin. Microbiol. 47, 3323 (2009), (6) J.M. Balkovec, et al., Nat. Prod. Rep. 31, 15 (2014)
InChi	InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72,21-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75),21H3,(H,3,4)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-,,/m0../s1
Quantity	5 mg, 25 mg, Bulk