Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- Yellow Powder
- Identity
- 1H-NMR
Properties
- Solvents
- " DMSO (10 mg/ml), 100% ethanol Inwater"
Category: Phytochemicals
Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. It displays anti-inflammatory, antitumor, neuroprotective, antioxidant and anti-diabetic properties. At a molecular level, Emodin inhibits casein kinase II, p56lck, NF-kappaB, 11β-HSD1, Estrogen receptor ERα and ERβ, androgen receptor (AR) nuclear translocation, VEGFR2, FGFR-1, EGFR, PDGFR-β, Kit and JAK2. It has also been described to inhibit the inflammasome, being a AMPK activator and PPARγ agonist and a P2X7 receptor antagonist.
Synonyms | Emodol, Frangulic acid, Archin, NSC 622947, NSC 408120, 1,3,8-Trihydroxy-6-methylanthraquinone, Schuttgelb |
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Purity | ≥97% (HPLC) |
Appearance | Yellow Powder |
CAS-Number | 518-82-1 |
Molecular Formula | C15H10O5 |
Molecular Weight | 270.24 |
Identity | 1H-NMR |
Solvents | " DMSO (10 mg/ml), 100% ethanol Inwater" |
Smiles | OC1=C2C(C(C(C=C(O)C=C3O)=C3C2=O)=O)=CC(C)=C1 |
InChi Key | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) Vasorelaxant effect of emodin, an anthraquinone from a Chinese herb: H.C. Huang, et al., Eur. J. Pharmacol. 205, 289 (1991), (2) Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum: H. Jayasuriya, et al., J. Nat. Prod. 55, 696 (1992), (3) Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells: A. Kumar, et al., Oncogene 17, 913 (1998), (4) Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor: H. Yim, et al., Planta Med. 65, 9 (1999), (5) Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity: H. Matsuda, et al., Bioorg. Med. Chem. Lett. 11, 1839 (2001), (6) Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth: T.L. Cha, et al., Cancer Res. 65, 2287 (2005), (7) Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor: A. Muto, et al., Mol. Cancer Ther. 6, 987 (2007), (8) Screening of Kit inhibitors: suppression of Kit signaling and melanogenesis by emodin: S.J. Lee, et al., Phytother. Res. 24, 308 (2010), (9) Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity: T. Liu, et al., Brain Res. 1347, 149 (2010), (10) Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor: L. Liu, et al., Eur. J. Pharmacol. 640, 15 (2010), (11) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice: Y. Feng, et al., Br. J. Pharmacol. 161, 113 (2010), (12) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity: Z. Chen, et al., J. Cell Biochem. 113, 3547 (2012), (13) The distinct mechanisms of the antitumor activity of emodin in different types of cancer: W.T. Wei, et al., Oncol. Rep. 30, 2555 (2013) (Review), (14) Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620: T. Pooja & D. Karunagaran, Eur. J. Pharmacol. 742, 55 (2014), (15) Anti-Inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation: J.W. Han, et al., Int. J. Mol. Sci. 16, 8102 (2015) |
InChi | InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3 |
Quantity | 250 mg, Bulk |