- Synonyms: BRN 0285801, N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide, STX 606, Sulfisomezole-N4-acetate
- Purity: ≥99% (HPLC)
- Appearance: White solid or crystals.
- CAS-Number: 21312-10-7
- Molecular Formula: C12H13N3O4S
- Molecular Weight: 295.3
- Identity: 1H-NMR
- Solvents: chloroform
- Smiles: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NOC(C)=C1
- InChi: InChI=1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15)
- InChi Key: GXPIUNZCALHVBA-UHFFFAOYSA-N
Available from stock
N4-Acetylsulfamethoxazole
SKU: A0291
Category: Metabolites
- Shipping: AMBIENT
- Short Term Storage: +4°C
- Long Term Storage: -20°C
- Handling Advice: Protect from light and moisture. Keep cool and dry.
- Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
- Description: This is a metabolite of the sulfonamide bacteriostatic antibiotic sulfamethoxazole. Sulfamethoxazole is metabolized via acetylation, catalyzed by liver extramitochondrial N-acetyl transferases. Acetyl-Sulfamethoxazole is excreted in urine. Both compounds can be used as a probe for the molecular percentage enrichement of liver extramitochondrial acetyl-CoA. Acetyl-Sulfamethoxazole can also be used as a reference for sulfamethoxazole impurity and waste determination.
- References: (1) T.B. Vree, et al.; Clin. Pharmacokinet. 3, 319 (1978), (2) R.M. Hutabarat, et al.; Clin. Pharmacol. Ther. 49, 402 (1991), (3) T. Heberer, et al.; Toxicol. Lett. 131, 5 (2002), (4) T.A. Larsen, et al.; J. Biotechnol. 113, 295 (2004), (5) K. Stein, et al.; Environ. Sci. Technol. 42, 6415 (2008)
This is a metabolite of the sulfonamide bacteriostatic antibiotic sulfamethoxazole. Sulfamethoxazole is metabolized via acetylation, catalyzed by liver extramitochondrial N-acetyl transferases. Acetyl-Sulfamethoxazole is excreted in urine. Both compounds can be used as a probe for the molecular percentage enrichement of liver extramitochondrial acetyl-CoA. Acetyl-Sulfamethoxazole can also be used as a reference for sulfamethoxazole impurity and waste determination.
Additional information
| Quantity | 10 mg, 50 mg, Bulk |
|---|---|
| Handling Advice | Protect from light and moisture. Keep cool and dry. |
| Availability | 1 |
| CAS-Number | 21312-10-7 |
| InChi | InChI=1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15) |
| Molecular Formula | |
| Appearance | White solid or crystals. |
| InChi Key | GXPIUNZCALHVBA-UHFFFAOYSA-N |
| Long Term Storage | -20°C |
| Identity | 1H-NMR |
| Short Term Storage | +4°C |
| Molecular Weight | |
| Pricetable | |
| References | (1) T.B. Vree, et al.; Clin. Pharmacokinet. 3, 319 (1978), (2) R.M. Hutabarat, et al.; Clin. Pharmacol. Ther. 49, 402 (1991), (3) T. Heberer, et al.; Toxicol. Lett. 131, 5 (2002), (4) T.A. Larsen, et al.; J. Biotechnol. 113, 295 (2004), (5) K. Stein, et al.; Environ. Sci. Technol. 42, 6415 (2008) |
| Shipping | AMBIENT |
| Smiles | CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NOC(C)=C1 |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Purity | |
| Solvents | chloroform |
| Synonyms | BRN 0285801, N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide, STX 606, Sulfisomezole-N4-acetate |
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