Specifications
- Purity
- ≥99% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White powder or crystals
Properties
- Solvents
- chloroform
Downloads
- Safety Data Sheet
- CDX A0291 MSDS.pdf
Available from stock
N4-Acetylsulfamethoxazole
- SKU
- A0291
Category: Metabolites
- Synonyms
- N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide , Sulfisomezole-N4-acetate , BRN 0285801 , STX 606
- 21312-10-7
- CAS-Number
- C12H13N3O4S
- Molecular Formula
- 295.3
- Molecular Weight
- Short Term Storage
- +4°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- This is a metabolite of the sulfonamide bacteriostatic antibiotic sulfamethoxazole. Sulfamethoxazole is metabolized via acetylation, catalyzed by liver extramitochondrial N-acetyl transferases. Acetyl-Sulfamethoxazole is excreted in urine. Both compounds can be used as a probe for the molecular percentage enrichement of liver extramitochondrial acetyl-CoA. Acetyl-Sulfamethoxazole can also be used as a reference for sulfamethoxazole impurity and waste determination.
- InChi
- InChI=1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15)
- References
- (1) T.B. Vree, et al.: Clin. Pharmacokinet. 3, 319 (1978) , (2) R.M. Hutabarat, et al.: Clin. Pharmacol. Ther. 49, 402 (1991) , (3) T. Heberer, et al.: Toxicol. Lett. 131, 5 (2002) , (4) T.A. Larsen, et al.: J. Biotechnol. 113, 295 (2004) , (5) K. Stein, et al.: Environ. Sci. Technol. 42, 6415 (2008)
- InChi Key
- GXPIUNZCALHVBA-UHFFFAOYSA-N
- Smiles
- CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NOC(C)=C1
This is a metabolite of the sulfonamide bacteriostatic antibiotic sulfamethoxazole. Sulfamethoxazole is metabolized via acetylation, catalyzed by liver extramitochondrial N-acetyl transferases. Acetyl-Sulfamethoxazole is excreted in urine. Both compounds can be used as a probe for the molecular percentage enrichement of liver extramitochondrial acetyl-CoA. Acetyl-Sulfamethoxazole can also be used as a reference for sulfamethoxazole impurity and waste determination.
Additional information
| Synonyms | N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide, Sulfisomezole-N4-acetate, BRN 0285801, STX 606 |
|---|---|
| Purity | ≥99% (HPLC) |
| Appearance | White powder or crystals |
| CAS-Number | 21312-10-7 |
| Molecular Formula | C12H13N3O4S |
| Molecular Weight | 295.3 |
| Identity | 1H-NMR |
| Solvents | chloroform |
| Smiles | CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NOC(C)=C1 |
| InChi Key | GXPIUNZCALHVBA-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) T.B. Vree, et al.: Clin. Pharmacokinet. 3, 319 (1978), (2) R.M. Hutabarat, et al.: Clin. Pharmacol. Ther. 49, 402 (1991), (3) T. Heberer, et al.: Toxicol. Lett. 131, 5 (2002), (4) T.A. Larsen, et al.: J. Biotechnol. 113, 295 (2004), (5) K. Stein, et al.: Environ. Sci. Technol. 42, 6415 (2008) |
| InChi | InChI=1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15) |
| Quantity | 10 mg, 50 mg, Bulk |
