Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Light yellow to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF (20 mg/ml), ethanol (1 mg/ml)
Downloads
- Safety Data Sheet
- CDX N0234 MSDS.pdf
Category: Phytochemicals
Naringin is a citrus-derived flavonoid (bitter principal). It undergoes extensive metabolism in the liver. It has a broad panel of properties, including anti-inflammatory, antioxidant, anticancer, antidiabetic, cardioprotective, bone regenerative and neuroprotective activities. Naringin acts by modulating several signaling pathway targets, activity is primarily attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and inflammatory transcription factors) and antioxidant (via scavenging of free radicals, bolstering of endogenous antioxidant defense system and metal ion chelation) effects. It increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.
Synonyms | 4',5,7-Trihydroxyflavanone 7-rhamnoglucoside, Naringenin 7-neohesperidoside, Naringenine-7-rhamnosidoglucoside, Naringoside, NSC 5548 |
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Purity | ≥98% (HPLC) |
Appearance | Light yellow to beige powder |
CAS-Number | 10236-47-2 |
Molecular Formula | C27H32O14 |
Molecular Weight | 580.54 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), DMF (20 mg/ml), ethanol (1 mg/ml) |
Smiles | OC1=C2C(OC(C3=CC=C(O)C=C3)CC2=O)=CC(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)=C1 |
InChi Key | DFPMSGMNTNDNHN-JJLSSNRUSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) U. Fuhr, et al., Br. J. Clin. Pharmacol. 35, 431 (1993), (2) P.C. Ho & D.J. Saville, J. Pharm. Pharmaceut. Sci. 4, 217 (2001), (3) S. Bharti, et al., Planta Med. 80, 437 (2014) (Review), (4) U.J. Jung, et al., Exp. Neurobiol. 23, 124 (2014) (Review), (5) M.A. Alam, et al., Adv. Nutr. 5, 404 (2014) (Review), (6) R. Chen, et al., Pharm. Biol. 54, 3203 (2016) (Review) |
InChi | InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16?,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1 |
Quantity | 100 g, Bulk |