Specifications
- Purity
- ≥98% (TLC)
- Appearance
- White to yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in methanol or ethanol. Insoluble in water.
Category: Antibiotics
Nigericin is an antibiotic, used as a high affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. It shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity and disrupts membrane potential of mitochondria. It sprimary use is as a NLRP3 activator in inflammasome research.
Synonyms | Antibiotic X464, Azalomycin M, Polyetherin A, Antibiotic K178, Helexin C |
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Purity | ≥98% (TLC) |
Appearance | White to yellow powder |
CAS-Number | 28643-80-3 |
Molecular Formula | C40H67NaO11 |
Molecular Weight | 746.94 |
Identity | 1H-NMR |
Solvents | Soluble in methanol or ethanol. Insoluble in water. |
Smiles | [Na+].[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C([O-])=O)C[C@]2([H])C[C@@H](OC)[C@@H](C)[C@]3(O2)O[C@@](C)(C[C@H]3C)[C@@]4([H])CC[C@](C)(O4)[C@]5([H])O[C@]([H])(C[C@@H]5C)[C@@]6([H])O[C@@](O)(CO)[C@H](C)C[C@@H]6C |
InChi Key | MOYOTUKECQMGHE-PDEFJWSRSA-M |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H301 – H319 |
Precautionary statements | P264 – P270 – P280 – P301 + P310 – P305 + P351 + P338 – P337 + P313 |
GHS Symbol | GHS06 |
Signal word | Danger |
RIDADR | UN3462 |
Transportation | Packing Group III |
References | (1) R. L. Harned, et al., Antibiot. Chemother. 1, 594 (1951), (2) S. Estrada-O, et al., J. Biol. Chem. 242, 2925 (1967), (3) D. Perregaux, et al., J. Immunol. 149, 1294 (1992), (4) B. Baibakov, et al., Int. J. Oncol. 3, 1127 (1993), (5) N. Watanabe, et al., Cytokine 10, 645 (1998), (6) S. Mariathasan, et al., Nature 440, 228 (2006), (7) C. Wang, et al., Sci. Immunol. 6, eabj3859 (2021) |
Quantity | 5 mg, 10 mg, 50 mg, Bulk |