Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in DMSO, ethanol or methanol. Insoluble in water.
- Melting Point
- 260° C
Category: Phytochemicals
Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite (ONOO-) and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-κB, MAPK, Nrf2, and AMPK. It can modulate Ca2+ channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.
Synonyms | 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 60-82-2 |
Molecular Formula | C15H14O5 |
Molecular Weight | 274.27 |
Identity | 1H-NMR |
Solvents | Soluble in DMSO, ethanol or methanol. Insoluble in water. |
Melting Point | 260° C |
Smiles | Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1 |
InChi Key | VGEREEWJJVICBM-UHFFFAOYSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H315 – H319 – H335 |
Precautionary statements | P261 – P264 – P271 – P280 – P302 + P352 – P305 + P351 + P338 |
GHS Symbol | GHS07 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) M.R. de Oliveira, Biofactors 42, 13 (2016) (Review), (2) B.Y. Choi, Molecules 24, 278 (2019) (Review), (3) T.P.A. Casarini, et al., Eur. J. Pharmacol. 889, 173593 (2020) (Review), (4) K.T. Nakhate, et al., Nutrients 14, 3638 (2022) (Review), (5) H.S. Tuli, et al., Molecules 27, 8819 (2022) (Review), (6) S. Habtemariam,, Biomedicines 11, 143 (2023) (Review) |
Quantity | 100 mg, 250 mg, Bulk |