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    (S)-(+)-Naproxene

    Available from stock

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      (S)-(+)-Naproxene

      SKU
      N0061

      Category: API's & Intermediates

      Synonyms
      (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid , Naprosyn , Equiproxen , Laraflex
      22204-53-1
      CAS-Number
      C14H14O3
      Molecular Formula
      230.26
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Identity
      1H-NMR
      Appearance
      White powder

      Properties

      Other
      pKa: 4.85
      Density
      1.20 g/cm3
      Refractive Index
      n20D 1.61
      Optical Activity
      [α]20/D 66º, c = 1 in chloroform
      Boiling Point
      403.9 °C at 760 mmHg
      Melting Point
      152-154 °C (lit.)
      Solvents
      water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate, tetrahydrofuran

      Downloads

      Safety Data Sheet
      CDX N0061 MSDS.pdf
      Short Term Storage
      +4°C
      Use / Stability
      Stable for at least 2 years after receipt when stored at +4°C.
      Handling Advice
      Protect from light and moisture.
      Long Term Storage
      +4°C
      Shipping
      AMBIENT
      Transportation
      Packing Group III
      RIDADR
      UN2811 6.1
      Signal word
      Danger
      GHS Symbol
      GHS06
      Precautionary statements
      P264, P270, P301 + P310, P321, P330, P405, P501
      Hazard statements
      H301
      Description
      Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).
      InChi
      InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
      References
      (1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970) , (2) R.N. Brogden, et al.: Drugs 18, 241-277 (1979) , (3) W.F. Kean, et al.: J. Pharm. Sci. 78, 324 (1989) , (4) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010) , (5) T. Takeda, et al.: J. Phys. Chem. B. 114, 15394 (2010) , (6) F. Dimiza, et al.: J. Inorg. Biochem. 105, 476 (2011)
      InChi Key
      CMWTZPSULFXXJA-UHFFFAOYSA-N
      Smiles
      C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1

      Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).

      SKU: N0061 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid, Naprosyn, Equiproxen, Laraflex

      Purity

      ≥98% (HPLC)

      Appearance

      White powder

      CAS-Number

      22204-53-1

      Molecular Formula

      C14H14O3

      Molecular Weight

      230.26

      Identity

      1H-NMR

      Solvents

      water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate, tetrahydrofuran

      Melting Point

      152-154 °C (lit.)

      Boiling Point

      403.9 °C at 760 mmHg

      Optical Activity

      [α]20/D 66º, c = 1 in chloroform

      Refractive Index

      n20D 1.61

      Density

      1.20 g/cm3

      Other

      pKa: 4.85

      Smiles

      C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1

      InChi Key

      CMWTZPSULFXXJA-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      +4°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at +4°C.

      Hazard statements

      H301

      Precautionary statements

      P264, P270, P301 + P310, P321, P330, P405, P501

      GHS Symbol

      GHS06

      Signal word

      Danger

      RIDADR

      UN2811 6.1

      Transportation

      Packing Group III

      References

      (1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970), (2) R.N. Brogden, et al.: Drugs 18, 241-277 (1979), (3) W.F. Kean, et al.: J. Pharm. Sci. 78, 324 (1989), (4) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010), (5) T. Takeda, et al.: J. Phys. Chem. B. 114, 15394 (2010), (6) F. Dimiza, et al.: J. Inorg. Biochem. 105, 476 (2011)

      InChi

      InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

      Quantity

      1 g, 10 g, Bulk

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