Available from stock
Category: API's & Intermediates
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).
| Synonyms | (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid, Naprosyn, Equiproxen, Laraflex |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White powder |
| CAS-Number | 22204-53-1 |
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.26 |
| Identity | 1H-NMR |
| Solvents | water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate, tetrahydrofuran |
| Melting Point | 152-154 °C (lit.) |
| Boiling Point | 403.9 °C at 760 mmHg |
| Optical Activity | [α]20/D 66º, c = 1 in chloroform |
| Refractive Index | n20D 1.61 |
| Density | 1.20 g/cm3 |
| Other | pKa: 4.85 |
| Smiles | C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1 |
| InChi Key | CMWTZPSULFXXJA-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Hazard statements | H301 |
| Precautionary statements | P264, P270, P301 + P310, P321, P330, P405, P501 |
| GHS Symbol | GHS06 |
| Signal word | Danger |
| RIDADR | UN2811 6.1 |
| Transportation | Packing Group III |
| References | (1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970), (2) R.N. Brogden, et al.: Drugs 18, 241-277 (1979), (3) W.F. Kean, et al.: J. Pharm. Sci. 78, 324 (1989), (4) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010), (5) T. Takeda, et al.: J. Phys. Chem. B. 114, 15394 (2010), (6) F. Dimiza, et al.: J. Inorg. Biochem. 105, 476 (2011) |
| InChi | InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16) |
| Quantity | 1 g, 10 g, Bulk |
5-Nonanol
