Available from stock

(S)-(+)-Naproxene

SKU: N0061

Category: API's & Intermediates

Synonyms: (S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid , Naprosyn , Equiproxen , Laraflex; 22204-53-1
CAS-Number: C₁₄H₁₄O₃
Molecular Formula: 230.26
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White powder
Identity: 1H-NMR

Properties

Solvents: water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate, tetrahydrofuran
Melting Point: 152-154 °C (lit.)
Boiling Point: 403.9 °C at 760 mmHg
Optical Activity: [α]20/D 66º, c = 1 in chloroform
Refractive Index: n20D 1.61
Density: 1.20 g/cm3
Other: pKa: 4.85

Documentation

Safety Data Sheet (SDS): CDX N0061 MSDS.pdf

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H301
Precautionary statements: P264, P270, P301 + P310, P321, P330, P405, P501
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN2811 6.1
Transportation: Packing Group III

Description: Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).
Smiles: C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
InChi Key: CMWTZPSULFXXJA-UHFFFAOYSA-N
References: (1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970) , (2) R.N. Brogden, et al.: Drugs 18, 241-277 (1979) , (3) W.F. Kean, et al.: J. Pharm. Sci. 78, 324 (1989) , (4) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010) , (5) T. Takeda, et al.: J. Phys. Chem. B. 114, 15394 (2010) , (6) F. Dimiza, et al.: J. Inorg. Biochem. 105, 476 (2011)
InChi: InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

Non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory compound that acts as a Cox (cyclooxygenase) inhibitor, and inhibits both Cox-1 and Cox-2. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).

SKU: N0061 Category: API's & Intermediates

Additional information

Additional information

Synonyms	(S)-(+)-6-Methoxy-α-methyl-2-naphthalene acetic acid, Naprosyn, Equiproxen, Laraflex
Purity	≥98% (HPLC)
Appearance	White powder
CAS-Number	22204-53-1
Molecular Formula	C14H14O3
Molecular Weight	230.26
Identity	1H-NMR
Solvents	water (>3 mg/ml at 25 °C), methanol, DMSO, DMF (100 mg/ml), chloroform, dichloromethane, ether, ethylacetate, tetrahydrofuran
Melting Point	152-154 °C (lit.)
Boiling Point	403.9 °C at 760 mmHg
Optical Activity	[α]20/D 66º, c = 1 in chloroform
Refractive Index	n20D 1.61
Density	1.20 g/cm3
Other	pKa: 4.85
Smiles	C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1
InChi Key	CMWTZPSULFXXJA-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H301
Precautionary statements	P264, P270, P301 + P310, P321, P330, P405, P501
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN2811 6.1
Transportation	Packing Group III
References	(1) I.T. Harrison et al., J. Med. Chem. 13, 203 (1970), (2) R.N. Brogden, et al.: Drugs 18, 241-277 (1979), (3) W.F. Kean, et al.: J. Pharm. Sci. 78, 324 (1989), (4) K.C. Duggan, et al.: J. Biol. Chem. 285, 34950 (2010), (5) T. Takeda, et al.: J. Phys. Chem. B. 114, 15394 (2010), (6) F. Dimiza, et al.: J. Inorg. Biochem. 105, 476 (2011)
InChi	InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
Quantity	1 g, 10 g, Bulk