Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White crystalline powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in methanol, ethanol or DMSO.
Category: Lipids, Fatty Acids
Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. Thapsigargin shows anti-inflammatory and anti-cancer effects.
Purity | ≥98% (HPLC) |
---|---|
Appearance | White crystalline powder |
CAS-Number | 67526-95-8 |
Molecular Formula | C34H50O12 |
Molecular Weight | 650.75 |
Identity | 1H-NMR |
Solvents | Soluble in methanol, ethanol or DMSO. |
Smiles | O=C1OC2C3=C(C)[C@@H](OC(/C(C)=C\C)=O)[C@@H](OC(CCCCCCC)=O)[C@]3([H])[C@](C)(OC(C)=O)C[C@@H](OC(CCC)=O)[C@]2(O)[C@@]1(O)C |
InChi Key | IXFPJGBNCFXKPI-IVRBKYRWSA-N |
Shipping | AMBIENT |
Short Term Storage | -20°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Hazard statements | H315 – H319 – H334 – H335 |
Precautionary statements | P261 – P264 – P271 – P302 + P352 – P304 + P340 + P312 – P305 + P351 + P338 |
GHS Symbol | GHS07+GHS08 |
Signal word | Danger |
Transportation | Not dangerous goods |
References | (1) S.A. Patkar, et al.; Agents Actions 9, 53 (1979), (2) H. Hakii, et al., J. Cancer. Res. Clin. Oncol. 111, 177 (1986), (3) Y. Sagara, & G. Inesi; J. Biol. Chem. 266, 13503 (1991), (4) A. Tsukamoto & Y. Kaneko; Cell Biol. Int. 17, 969 (1993), (5) J.P. Beaver & P. Waring; Cell Death Differ. 3, 415 (1996), (6) M. Treiman, et al.; Trends Pharmacol. Sci. 19,131 (1998), (7) B. Tombal, et al.; Prostate 43, 303 (2000), (8) S.B. Christensen, et al.; Anticancer Agents Med. Chem. 9, 276 (2009), (9) N.T. Quynh Doan & S.B. Christensen; Curr. Pharm. Des. 21, 5501 (2015) (Review), (10) N.T. Doan, et al.; Steroids 97, 2 (2015) (Review), (11) A. Jaskulska, et al.; Int. J. Mol. Sci. 22, 4 (2020) (Review) |
InChi | (1) N.A. Kuznetsova et al.: Russ. J. Gen. Chem. 71, 36 (2001) |
Quantity | 1 mg, 5 mg, Bulk |