Tianeptine sodium salt

SKU: T0456

Category: Amino Acids, Peptides, Proteins

Synonyms: 7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt , S-1574 , Stablon; 30123-17-2
CAS-Number: C₂₁H₂₄ClN₂NaO₄S
Molecular Formula: 458.93
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (T)
Identity: 1H-NMR
Appearance: White to pale yellow solid

Properties

Solvents: DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml), water (10mg/ml).

Short Term Storage: RT
Use / Stability: Stable for at least 2 years after receipt when stored at RT.
Handling Advice: Very hygroscopic. Store under inert gas.
Long Term Storage: RT
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.
References: (1) T. Mennini, et al., Naunyn Schmiedebergs Arch. Pharmacol. 336, 478 (1987) , (2) R. Defrance, et al., Clin. Neuropharmacol. 11, S74 (1988) (Review) , (3) M.G. Simoni, et al., Brain Res. 574, 93 (1992) , (4) I.T. Uzbay, et al. , Life Sci. 64, 1313 (1999) , (5) A.J. Wagstaff, et al., CNS Drugs 15, 231 (2001) , (6) F. Plaisant, et al., Neuropharmacol. 44, 801 (2003) , (7) B.S. McEwen, et al. , Mol. Psych. 15, 237 (2010) , (8) V. Szegedi, et al., Neurochem. Int. 59, 1109 (2011) , (9) S.S. Bilge, et al., Eur. J. Pharmacol. 681, 44 (2012) , (10) H. Zhang, et al., Mol. Psych. 18, 471 (2013) , (11) M.M. Gassaway, et al., Transl. Psych. 4, 1 (2014) , (12) D. Jantas, et al., Neurotox. Res. 25, 208 (2014) , (13) M.K. Seo, et al., Psychopharmacol. 233, 2617 (2016) , (14) J. Slusarczyk, et al., Int. J. Mol. Sci. 19, E1965 (2018)
InChi Key: ZLBSUOGMZDXYKE-UHFFFAOYSA-M
Smiles: ClC(C=C1)=CC2=C1C(NCCCCCCC([O-])=O)C(C=CC=C3)=C3N(C)S2(=O)=O.[Na+]

Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.

SKU: T0456 Category: Amino Acids, Peptides, Proteins

Additional information

Additional information

Synonyms	7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt, S-1574, Stablon
Purity	≥98% (T)
Appearance	White to pale yellow solid
CAS-Number	30123-17-2
Molecular Formula	C21H24ClN2NaO4S
Molecular Weight	458.93
Identity	1H-NMR
Solvents	DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml), water (10mg/ml).
Smiles	ClC(C=C1)=CC2=C1C(NCCCCCCC([O-])=O)C(C=CC=C3)=C3N(C)S2(=O)=O.[Na+]
InChi Key	ZLBSUOGMZDXYKE-UHFFFAOYSA-M
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Very hygroscopic. Store under inert gas.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Transportation	Not dangerous goods
References	(1) T. Mennini, et al., Naunyn Schmiedebergs Arch. Pharmacol. 336, 478 (1987), (2) R. Defrance, et al., Clin. Neuropharmacol. 11, S74 (1988) (Review), (3) M.G. Simoni, et al., Brain Res. 574, 93 (1992), (4) I.T. Uzbay, et al. , Life Sci. 64, 1313 (1999), (5) A.J. Wagstaff, et al., CNS Drugs 15, 231 (2001), (6) F. Plaisant, et al., Neuropharmacol. 44, 801 (2003), (7) B.S. McEwen, et al. , Mol. Psych. 15, 237 (2010), (8) V. Szegedi, et al., Neurochem. Int. 59, 1109 (2011), (9) S.S. Bilge, et al., Eur. J. Pharmacol. 681, 44 (2012), (10) H. Zhang, et al., Mol. Psych. 18, 471 (2013), (11) M.M. Gassaway, et al., Transl. Psych. 4, 1 (2014), (12) D. Jantas, et al., Neurotox. Res. 25, 208 (2014), (13) M.K. Seo, et al., Psychopharmacol. 233, 2617 (2016), (14) J. Slusarczyk, et al., Int. J. Mol. Sci. 19, E1965 (2018)
Quantity	500 mg, 1 g, Bulk