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    Tianeptine sodium salt

    Available from stock

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      Tianeptine sodium salt

      SKU
      T0456

      Category: Amino Acids, Peptides, Proteins

      Synonyms
      7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt , S-1574 , Stablon
      30123-17-2
      CAS-Number
      C21H24ClN2NaO4S
      Molecular Formula
      458.93
      Molecular Weight

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (T)
      Identity
      1H-NMR
      Appearance
      White to pale yellow solid

      Properties

      Solvents
      DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml), water (10mg/ml).
      Short Term Storage
      RT
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Handling Advice
      Very hygroscopic. Store under inert gas.
      Long Term Storage
      RT
      Shipping
      AMBIENT
      Transportation
      Not dangerous goods
      Description
      Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.
      References
      (1) T. Mennini, et al., Naunyn Schmiedebergs Arch. Pharmacol. 336, 478 (1987) , (2) R. Defrance, et al., Clin. Neuropharmacol. 11, S74 (1988) (Review) , (3) M.G. Simoni, et al., Brain Res. 574, 93 (1992) , (4) I.T. Uzbay, et al. , Life Sci. 64, 1313 (1999) , (5) A.J. Wagstaff, et al., CNS Drugs 15, 231 (2001) , (6) F. Plaisant, et al., Neuropharmacol. 44, 801 (2003) , (7) B.S. McEwen, et al. , Mol. Psych. 15, 237 (2010) , (8) V. Szegedi, et al., Neurochem. Int. 59, 1109 (2011) , (9) S.S. Bilge, et al., Eur. J. Pharmacol. 681, 44 (2012) , (10) H. Zhang, et al., Mol. Psych. 18, 471 (2013) , (11) M.M. Gassaway, et al., Transl. Psych. 4, 1 (2014) , (12) D. Jantas, et al., Neurotox. Res. 25, 208 (2014) , (13) M.K. Seo, et al., Psychopharmacol. 233, 2617 (2016) , (14) J. Slusarczyk, et al., Int. J. Mol. Sci. 19, E1965 (2018)
      InChi Key
      ZLBSUOGMZDXYKE-UHFFFAOYSA-M
      Smiles
      ClC(C=C1)=CC2=C1C(NCCCCCCC([O-])=O)C(C=CC=C3)=C3N(C)S2(=O)=O.[Na+]

      Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.

      SKU: T0456 Category: Amino Acids, Peptides, Proteins
      • Additional information

      Additional information

      Synonyms

      7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt, S-1574, Stablon

      Purity

      ≥98% (T)

      Appearance

      White to pale yellow solid

      CAS-Number

      30123-17-2

      Molecular Formula

      C21H24ClN2NaO4S

      Molecular Weight

      458.93

      Identity

      1H-NMR

      Solvents

      DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml), water (10mg/ml).

      Smiles

      ClC(C=C1)=CC2=C1C(NCCCCCCC([O-])=O)C(C=CC=C3)=C3N(C)S2(=O)=O.[Na+]

      InChi Key

      ZLBSUOGMZDXYKE-UHFFFAOYSA-M

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Very hygroscopic. Store under inert gas.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Transportation

      Not dangerous goods

      References

      (1) T. Mennini, et al., Naunyn Schmiedebergs Arch. Pharmacol. 336, 478 (1987), (2) R. Defrance, et al., Clin. Neuropharmacol. 11, S74 (1988) (Review), (3) M.G. Simoni, et al., Brain Res. 574, 93 (1992), (4) I.T. Uzbay, et al. , Life Sci. 64, 1313 (1999), (5) A.J. Wagstaff, et al., CNS Drugs 15, 231 (2001), (6) F. Plaisant, et al., Neuropharmacol. 44, 801 (2003), (7) B.S. McEwen, et al. , Mol. Psych. 15, 237 (2010), (8) V. Szegedi, et al., Neurochem. Int. 59, 1109 (2011), (9) S.S. Bilge, et al., Eur. J. Pharmacol. 681, 44 (2012), (10) H. Zhang, et al., Mol. Psych. 18, 471 (2013), (11) M.M. Gassaway, et al., Transl. Psych. 4, 1 (2014), (12) D. Jantas, et al., Neurotox. Res. 25, 208 (2014), (13) M.K. Seo, et al., Psychopharmacol. 233, 2617 (2016), (14) J. Slusarczyk, et al., Int. J. Mol. Sci. 19, E1965 (2018)

      Quantity

      500 mg, 1 g, Bulk

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