Specifications
- Purity
- ≥98% (T)
- Appearance
- White to pale yellow solid
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml), water (10mg/ml).
Category: Amino Acids, Peptides, Proteins
Tianeptine is an atypical antidepressant with diverse actions, most notably on the glutamatergic system. It is a selective facilitator of 5-HT (serotonin) uptake in vitro and in vivo. It attenuates glutamate release and modulates the function of the AMPA receptor. Tianeptine also acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641nM for human and mouse receptors, respectively). Might have anti-inflammatory properties through modulation of TLR and NLRP3 inflammasome signaling pathways.
Synonyms | 7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt, S-1574, Stablon |
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Purity | ≥98% (T) |
Appearance | White to pale yellow solid |
CAS-Number | 30123-17-2 |
Molecular Formula | C21H24ClN2NaO4S |
Molecular Weight | 458.93 |
Identity | 1H-NMR |
Solvents | DMSO (20mg/ml), DMF (30mg/ml), ethanol (10mg/ml), water (10mg/ml). |
Smiles | ClC(C=C1)=CC2=C1C(NCCCCCCC([O-])=O)C(C=CC=C3)=C3N(C)S2(=O)=O.[Na+] |
InChi Key | ZLBSUOGMZDXYKE-UHFFFAOYSA-M |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Very hygroscopic. Store under inert gas. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Transportation | Not dangerous goods |
References | (1) T. Mennini, et al., Naunyn Schmiedebergs Arch. Pharmacol. 336, 478 (1987), (2) R. Defrance, et al., Clin. Neuropharmacol. 11, S74 (1988) (Review), (3) M.G. Simoni, et al., Brain Res. 574, 93 (1992), (4) I.T. Uzbay, et al. , Life Sci. 64, 1313 (1999), (5) A.J. Wagstaff, et al., CNS Drugs 15, 231 (2001), (6) F. Plaisant, et al., Neuropharmacol. 44, 801 (2003), (7) B.S. McEwen, et al. , Mol. Psych. 15, 237 (2010), (8) V. Szegedi, et al., Neurochem. Int. 59, 1109 (2011), (9) S.S. Bilge, et al., Eur. J. Pharmacol. 681, 44 (2012), (10) H. Zhang, et al., Mol. Psych. 18, 471 (2013), (11) M.M. Gassaway, et al., Transl. Psych. 4, 1 (2014), (12) D. Jantas, et al., Neurotox. Res. 25, 208 (2014), (13) M.K. Seo, et al., Psychopharmacol. 233, 2617 (2016), (14) J. Slusarczyk, et al., Int. J. Mol. Sci. 19, E1965 (2018) |
Quantity | 500 mg, 1 g, Bulk |