Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, DMF, ethanol (all 20 mg/ml), water (1 mg/ml)
Category: Phytochemicals
Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants. It inhibits squalene epoxidase, a key enzyme in cholesterol synthesis and has various anti-inflammatory and anti-cancer effects. This compound displays the ability to inhibit NF?B pathway activation and also prevent the release of TNF-α. Additional studies show that Corilagin significantly inhibits type 1 plasminogen activator inhibitor (PAI-1) in rat plasma. Shown to have antioxidant, antiviral and hepatoprotective properties. Induces apoptosis, autophagy and ROS generation in several cell lines.
Synonyms | 1-O-Galloyl-3,6-hexahydroxydiphenol-β-D-Glucopyranose |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 23094-69-1 |
Molecular Formula | C27H22O18 |
Molecular Weight | 634.45 |
Identity | 1H-NMR |
Solvents | DMSO, DMF, ethanol (all 20 mg/ml), water (1 mg/ml) |
Smiles | O=C(O[C@H]([C@H]1O)[C@H](O)[C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC3=O)C4=CC(O)=C(O)C(O)=C4C5=C3C=C(O)C(O)=C5O |
InChi Key | TUSDEZXZIZRFGC-XIGLUPEJSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) I. Abe, et al., J. Nat. Prod. 64, 1010 (2001), (2) S. Okabe, et al., Biol. Pharm. Bull. 24, 1145 (2001), (3) Z.Q. Shen, et al., Planta Med. 69, 1109 (2003), (4) S. Shiota, et al., Microbiol. Immunol. 48, 67 (2004), (5) S. Kinoshita, et al., Phytomedicine 14, 755 (2007), (6) X.R. Dong, et al., Int. J. Mol. Med. 25, 531 (2010), (7) R. Gambari, et al., Intern. Immunopharmacol. 13, 308 (2012), (8) H.T. Xiao, et al., J. Nat. Prod. 76, 2120 (2013), (9) L. Jia, et al., BMC Complement. Altern. Med. 13, 33 (2013), (10) R. Gambari, et al., Phytother. Res. 28, 781 (2014), (11) H.R. Li, et al., BMC Complement. Altern. Med. 17, 18 (2017), (12) B.U. Reddy, et al., Antiviral Res. 150, 47 (2018), (13) X. Li, et al., Biomed. Pharmacother. 99, 43 (2018) (Review), (14) J. Xu, et al., Int. J. Mol. Med. 43, 967 (2019), (15) H.S. Nandini & P.R. Naik, Chem. Biol. Interact. 299, 186 (2019) |
Quantity | 10 mg, 50 mg, Bulk |