Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Solid
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, DMF, water (slightly), methanol (slightly), chloroform (slightly)
Category: API's & Intermediates
Clomiphene is a nonsteroidal triphenylethylene derivative. It acts as a selective estrogen receptor modulator (SERM), that impairs the activation of estrogen receptors (ERs) by 17β-estradiol, similar to tamoxifen and raloxifene. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation. Triphenylethylene antiestrogens may also be used as antileukemic drugs which kill cells by apoptosis mediated by oxidative stress and activation of PKC.
Synonyms | Clomifene, Omifin, NSC 35770, 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine, Clomiphene citrate salt |
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Purity | ≥98% (HPLC) |
Appearance | Solid |
CAS-Number | 50-41-9 |
Molecular Formula | C26H28ClNO · C6H8O7 |
Molecular Weight | 598.08 |
Identity | 1H-NMR |
Solvents | DMSO, DMF, water (slightly), methanol (slightly), chloroform (slightly) |
Smiles | Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O |
InChi Key | PYTMYKVIJXPNBD-BTKVJIOYSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H361 |
Precautionary statements | P281 |
GHS Symbol | GHS08 |
Signal word | Warning |
Transportation | Not dangerous goods |
References | (1) J.H. Clark & B.M. Markaverich, Pharmacol. Ther. 15, 467 (1981), (2) E.Y. Adashi, Fertil. Steril. 42, 331 (1984), (3) E. Kousta, et al., Hum. Reprod. Update 3, 359 (1997), (4) G.G.J.M. Kuiper, et al., Endocrinology 138, 863 (1997), (5) T. Hayon, et al., Anticancer Res. 19, 2089 (1999), (6) S.G. Haskell, South Med. J. 96, 469 (2003), (7) R. Homburg, Hum. Reprod. 20, 2043 (2005), (8) M. Amita, et al., Endocrinology 151, 394 (2010) |
Quantity | 1 g, 5 g, Bulk |