Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (3 mg/ml)
- Optical Activity
- 55.8° (c = 0.5 in ethanol)
Category: Phytochemicals
Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-?B activity by NF-?B-specific suppressor I?Bα. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.
Synonyms | BN-52020 |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White powder |
CAS-Number | 15291-75-5 |
Molecular Formula | C20H24O9 |
Molecular Weight | 408.40 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), DMF (20 mg/ml), ethanol (3 mg/ml) |
Optical Activity | 55.8° (c = 0.5 in ethanol) |
Smiles | O=C1[C@@H](C)[C@]([C@](O1)([H])C2)(O)[C@]([C@]32[C@H]4C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O |
InChi Key | FPUXKXIZEIDQKW-VKMVSBOZSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) H.W. Zhao & X.Y. Li, Int. Immunopharmacol. 2, 1551 (2002), (2) H. Kuribara, et al., J. Nat. Prod. 66, 1333 (2003), (3) E. Koch, Phytomedicine 12, 10 (2005), (4) B. Ye, et al., Cancer Lett. 251, 43 (2007), (5) Q. Zhao, et al., Int. Immunopharmacol. 25, 242 (2015), (6) N. Ye, et al., Biomol. Ther. 24, 40 (2016), (7) J. Zhaocheng, et al., Pharmazie 71, 588 (2016), (8) H.S. Jeong, et al., Biomed. Pharmacother. 88, 625 (2017), (9) Y. Li, et al., Int. J. Mol. Sci. 18, E794 (2017), (10) L.C. Kuo, et al., J. Agric. Food Chem. 67, 81 (2019), (11) S. Mohandas & B. Vairappan, Chem. Biol. Interact. 315, 108891 (2019), (12) W. You, et al., Pharmazie 74, 698 (2019) |
InChi | InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18+,19-,20-/m1/s1 |
Quantity | 25 mg, Bulk |