Available from stock

Hyperoside

SKU: H0298

Category: Phytochemicals

Synonyms: 3,3',4',5,7-Pentahydroxyflavone 3-D-galactoside , Hyperin , Quercetin 3-D-galactoside , NSC 407304; 482-36-0
CAS-Number: C₂₁H₂₀O₁₂
Molecular Formula: 464.38
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Yellow powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml), DMF (10 mg/ml)
Melting Point: 220-230° C
Refractive Index: 1.80 (Predicted)
Density: ~1.9 g/cm3

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Hyperoside is a 3-O-galactoside of quercetin that can be found in a wide range of plants. It shows diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, antihypoglycemic and antiadipogenic, antibacterial and anticancer properties. It has powerful antioxidant action through its ability to scavenge free radicals. It inhibits the NF-&kappa,B signaling pathway. Hyperoside selectively interrupted NLRC4 and AIM2 inflammasome activation but did not alter cytokine expression. The quorum sensing-inhibiting effect of hyperoside may lead to a reduction in biofilm formation in P. aeruginosa. Honokiol exerts broad-range anticancer activity, such as induction of apoptosis and autophagy and inhibition of cell proliferation. Hyperoside has a beneficial effect on the prevention and treatment of obesity.
Smiles: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)=C1O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O
InChi Key: OVSQVDMCBVZWGM-DTGCRPNFSA-N
References: (1) M.J. Piao, et al., Biochim. Biophys. Acta 1780, 1448 (2008) , (2) S.J. Kim, et al., Am. J. Chin. Med. 39, 171 (2011) , (3) K.W. Zeng, et al., Eur. J. Pharmacol. 672, 45 (2011) , (4) N. Zhang, et al., PLoS One 9, e98973 (2014) , (5) S.K. Ku, et al., Inflammation 38, 784 (2015) , (6) T. Fu, et al., Acta Pharmacol. Sin. 37, 505 (2016) , (7) P. Lu, Biomed. Pharmacother. 82, 216 (2016) , (8) H. Ahn & G.S. Lee, Phytomedicine 24, 77 (2017) , (9) Y. Sun, et al., Exp. Ther. Med. 14, 1647 (2017) , (10) Y. Zhang, et al., Int. J. Mol. Med. 41, 77 (2018) , (11) M. Berkoz, Acta Endocrinol. 15, 165 (2019)
InChi: InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1

Hyperoside is a 3-O-galactoside of quercetin that can be found in a wide range of plants. It shows diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, antihypoglycemic and antiadipogenic, antibacterial and anticancer properties. It has powerful antioxidant action through its ability to scavenge free radicals. It inhibits the NF-&kappa,B signaling pathway. Hyperoside selectively interrupted NLRC4 and AIM2 inflammasome activation but did not alter cytokine expression. The quorum sensing-inhibiting effect of hyperoside may lead to a reduction in biofilm formation in P. aeruginosa. Honokiol exerts broad-range anticancer activity, such as induction of apoptosis and autophagy and inhibition of cell proliferation. Hyperoside has a beneficial effect on the prevention and treatment of obesity.

SKU: H0298 Category: Phytochemicals

Additional information

Additional information

Synonyms	3,3',4',5,7-Pentahydroxyflavone 3-D-galactoside, Hyperin, Quercetin 3-D-galactoside, NSC 407304
Purity	≥98% (HPLC)
Appearance	Yellow powder
CAS-Number	482-36-0
Molecular Formula	C21H20O12
Molecular Weight	464.38
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), DMF (10 mg/ml)
Melting Point	220-230° C
Refractive Index	1.80 (Predicted)
Density	~1.9 g/cm3
Smiles	O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)=C1O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O
InChi Key	OVSQVDMCBVZWGM-DTGCRPNFSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) M.J. Piao, et al., Biochim. Biophys. Acta 1780, 1448 (2008), (2) S.J. Kim, et al., Am. J. Chin. Med. 39, 171 (2011), (3) K.W. Zeng, et al., Eur. J. Pharmacol. 672, 45 (2011), (4) N. Zhang, et al., PLoS One 9, e98973 (2014), (5) S.K. Ku, et al., Inflammation 38, 784 (2015), (6) T. Fu, et al., Acta Pharmacol. Sin. 37, 505 (2016), (7) P. Lu, Biomed. Pharmacother. 82, 216 (2016), (8) H. Ahn & G.S. Lee, Phytomedicine 24, 77 (2017), (9) Y. Sun, et al., Exp. Ther. Med. 14, 1647 (2017), (10) Y. Zhang, et al., Int. J. Mol. Med. 41, 77 (2018), (11) M. Berkoz, Acta Endocrinol. 15, 165 (2019)
InChi	InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1
Quantity	25 mg, Bulk