Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), DMF (10 mg/ml)
- Melting Point
- 220-230° C
- Refractive Index
- 1.80 (Predicted)
- Density
- ~1.9 g/cm3
Category: Phytochemicals
Hyperoside is a 3-O-galactoside of quercetin that can be found in a wide range of plants. It shows diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, antihypoglycemic and antiadipogenic, antibacterial and anticancer properties. It has powerful antioxidant action through its ability to scavenge free radicals. It inhibits the NF-&kappa,B signaling pathway. Hyperoside selectively interrupted NLRC4 and AIM2 inflammasome activation but did not alter cytokine expression. The quorum sensing-inhibiting effect of hyperoside may lead to a reduction in biofilm formation in P. aeruginosa. Honokiol exerts broad-range anticancer activity, such as induction of apoptosis and autophagy and inhibition of cell proliferation. Hyperoside has a beneficial effect on the prevention and treatment of obesity.
Synonyms | 3,3',4',5,7-Pentahydroxyflavone 3-D-galactoside, Hyperin, Quercetin 3-D-galactoside, NSC 407304 |
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Purity | ≥98% (HPLC) |
Appearance | Yellow powder |
CAS-Number | 482-36-0 |
Molecular Formula | C21H20O12 |
Molecular Weight | 464.38 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), DMF (10 mg/ml) |
Melting Point | 220-230° C |
Refractive Index | 1.80 (Predicted) |
Density | ~1.9 g/cm3 |
Smiles | O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)=C1O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O |
InChi Key | OVSQVDMCBVZWGM-DTGCRPNFSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) M.J. Piao, et al., Biochim. Biophys. Acta 1780, 1448 (2008), (2) S.J. Kim, et al., Am. J. Chin. Med. 39, 171 (2011), (3) K.W. Zeng, et al., Eur. J. Pharmacol. 672, 45 (2011), (4) N. Zhang, et al., PLoS One 9, e98973 (2014), (5) S.K. Ku, et al., Inflammation 38, 784 (2015), (6) T. Fu, et al., Acta Pharmacol. Sin. 37, 505 (2016), (7) P. Lu, Biomed. Pharmacother. 82, 216 (2016), (8) H. Ahn & G.S. Lee, Phytomedicine 24, 77 (2017), (9) Y. Sun, et al., Exp. Ther. Med. 14, 1647 (2017), (10) Y. Zhang, et al., Int. J. Mol. Med. 41, 77 (2018), (11) M. Berkoz, Acta Endocrinol. 15, 165 (2019) |
InChi | InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15+,17+,18-,21+/m1/s1 |
Quantity | 25 mg, Bulk |