Specifications
- Purity
- ≥97% (HPLC)
- Appearance
- Light yellow powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (5 mg/ml), DMF
Documentation
- Safety Data Sheet (SDS)
- CDX A0568 SDS_Vs1.1.pdf
Available from stock
Apigenin 7-glucoside
- SKU
- A0568
Category: Phytochemicals
- Synonyms
- Apigetrin , Cosmosiin , 4?,5,7-Trihydroxyflavone 7-glucoside , 7-O-β-D-Glucopyranosylapigenin , Apigenin-7-O-β-D-glucoside , NSC 407303
- 578-74-5
- CAS-Number
- C21H20O10
- Molecular Formula
- 432.38
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- -20°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Transportation
- Not dangerous goods
- Description
- Apigenin 7-glucoside is a flavonoid with anti-inflammatory, antioxidant, anticancer, anti-adipogenic and anxiolytic activities. It has been shown to inhibit LPS-induced nitric oxide production in RAW 264.7 cells or have hepatoprotective activity due to it's antioxidant activities, acting as scavengers of ROS. Apigenin 7-glucoside has been shown to have anti-proliferative activity, possible through cell cycle inhibition and consequently induce apoptosis. it also has the ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside has shown neuroprotective effects possibly by inhibiting neuroinflammation and its antioxidant activity. Apigenin-7-O-glucoside inhibits adipogenesis of 3T3-L1 preadipocytes at early stage of adipogenesis at high concentrations, by downregulating PPARγ and CEBP-α.
- Smiles
- O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(OC(C3=CC=C(O)C=C3)=CC4=O)=C4C(O)=C2)[C@@H]1O
- InChi Key
- KMOUJOKENFFTPU-QNDFHXLGSA-N
- References
- (1) J. Fuchs & R. Milbradt, Arzneimittelforschung 43, 370 (1993) , (2) Q.S. Zheng, et al., Biomed. Environ. Sci. 18, 65 (2005) , (3) E. Nakazaki, et al., Eur. J. Nutr. 52, 25 (2013) , (4) D. Kumar & Z.A. Bhat, Phytomedicine 21, 1010 (2014) , (5) N. Nasr Bouzaiene, et al., Life Sci. 144, 80 (2016) , (6) H.S. Lim, et al., J. Med. Food 19, 1032 (2016) , (7) Q. Sun, et al., BBRC 498, 164 (2018) , (8) F. Hadrich & S. Sayadi, Lipids Health Dis. 17, 95 (2018) , (9) H. Guo, et al., Biomed. Pharmacother. 109, 1978 (2019)
- InChi
- InChI=1S/C21H20O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-7,16,18-24,26-28H,8H2/t16-,18-,19+,20-,21-/m1/s1
Apigenin 7-glucoside is a flavonoid with anti-inflammatory, antioxidant, anticancer, anti-adipogenic and anxiolytic activities. It has been shown to inhibit LPS-induced nitric oxide production in RAW 264.7 cells or have hepatoprotective activity due to it’s antioxidant activities, acting as scavengers of ROS. Apigenin 7-glucoside has been shown to have anti-proliferative activity, possible through cell cycle inhibition and consequently induce apoptosis. it also has the ability to enhance melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells. Apigenin 7-glucoside has shown neuroprotective effects possibly by inhibiting neuroinflammation and its antioxidant activity. Apigenin-7-O-glucoside inhibits adipogenesis of 3T3-L1 preadipocytes at early stage of adipogenesis at high concentrations, by downregulating PPARγ and CEBP-α.
Additional information
| Synonyms | Apigetrin, Cosmosiin, 4?,5,7-Trihydroxyflavone 7-glucoside, 7-O-β-D-Glucopyranosylapigenin, Apigenin-7-O-β-D-glucoside, NSC 407303 |
|---|---|
| Purity | ≥97% (HPLC) |
| Appearance | Light yellow powder |
| CAS-Number | 578-74-5 |
| Molecular Formula | C21H20O10 |
| Molecular Weight | 432.38 |
| Identity | 1H-NMR |
| Solvents | DMSO (5 mg/ml), DMF |
| Smiles | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(OC(C3=CC=C(O)C=C3)=CC4=O)=C4C(O)=C2)[C@@H]1O |
| InChi Key | KMOUJOKENFFTPU-QNDFHXLGSA-N |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) J. Fuchs & R. Milbradt, Arzneimittelforschung 43, 370 (1993), (2) Q.S. Zheng, et al., Biomed. Environ. Sci. 18, 65 (2005), (3) E. Nakazaki, et al., Eur. J. Nutr. 52, 25 (2013), (4) D. Kumar & Z.A. Bhat, Phytomedicine 21, 1010 (2014), (5) N. Nasr Bouzaiene, et al., Life Sci. 144, 80 (2016), (6) H.S. Lim, et al., J. Med. Food 19, 1032 (2016), (7) Q. Sun, et al., BBRC 498, 164 (2018), (8) F. Hadrich & S. Sayadi, Lipids Health Dis. 17, 95 (2018), (9) H. Guo, et al., Biomed. Pharmacother. 109, 1978 (2019) |
| InChi | InChI=1S/C21H20O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-7,16,18-24,26-28H,8H2/t16-,18-,19+,20-,21-/m1/s1 |
| Quantity | 5 mg, 10 mg, 25 mg, Bulk |
