Articaine hydrochloride

SKU: A0564

Category: API's & Intermediates

Synonyms: 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride , Carticaine chlorhydrate , Carticaine hydrochloride , HOE 045 , HOE 40045 , Ultracaine; 23964-57-0
CAS-Number: C₁₃H₂₀N₂O₃S . HCl
Molecular Formula: 320.84
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Identity: 1H-NMR
Appearance: White to beige powder

Properties

Solvents: water (20 mg/ml), DMSO (15mg/ml), ethanol (5mg/ml).

Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Long Term Storage: -20°C
Short Term Storage: +4°C
Shipping: AMBIENT

Transportation: Not dangerous goods
Signal word: Warning
GHS Symbol: GHS07
Precautionary statements: P305 + P351 + P338
Hazard statements: H315-H319-H335

Description: Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
References: (1) S.F. Malamed, et al., J. Am. Dent. Assoc. 131, 635 (2000) , (2) G.K. Wang, et al., J. Membr. Biol. 229, 1 (2009) , (3) M. Snoeck, Local Reg. Anesth. 5, 23 (2012) (Review)
InChi Key: GDWDBGSWGNEMGJ-UHFFFAOYSA-N
Smiles: CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl

Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.

SKU: A0564 Category: API's & Intermediates

Additional information

Additional information

Synonyms	4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride, Carticaine chlorhydrate, Carticaine hydrochloride, HOE 045, HOE 40045, Ultracaine
Purity	≥98% (HPLC)
Appearance	White to beige powder
CAS-Number	23964-57-0
Molecular Formula	C13H20N2O3S . HCl
Molecular Weight	320.84
Identity	1H-NMR
Solvents	water (20 mg/ml), DMSO (15mg/ml), ethanol (5mg/ml).
Smiles	CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl
InChi Key	GDWDBGSWGNEMGJ-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H315-H319-H335
Precautionary statements	P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) S.F. Malamed, et al., J. Am. Dent. Assoc. 131, 635 (2000), (2) G.K. Wang, et al., J. Membr. Biol. 229, 1 (2009), (3) M. Snoeck, Local Reg. Anesth. 5, 23 (2012) (Review)
Quantity	500 mg, Bulk