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    Articaine hydrochloride

    Available from stock

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      Articaine hydrochloride

      SKU
      A0564

      Category: API's & Intermediates

      Synonyms
      4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride , Carticaine chlorhydrate , Carticaine hydrochloride , HOE 045 , HOE 40045 , Ultracaine
      23964-57-0
      CAS-Number
      C13H20N2O3S . HCl
      Molecular Formula
      320.84
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Appearance
      White to beige powder
      Identity
      1H-NMR

      Properties

      Solvents
      water (20 mg/ml), DMSO (15mg/ml), ethanol (5mg/ml).
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Hazard statements
      H315-H319-H335
      Precautionary statements
      P305 + P351 + P338
      GHS Symbol
      GHS07
      Signal word
      Warning
      Transportation
      Not dangerous goods
      Description
      Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
      Smiles
      CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl
      InChi Key
      GDWDBGSWGNEMGJ-UHFFFAOYSA-N
      References
      (1) S.F. Malamed, et al., J. Am. Dent. Assoc. 131, 635 (2000) , (2) G.K. Wang, et al., J. Membr. Biol. 229, 1 (2009) , (3) M. Snoeck, Local Reg. Anesth. 5, 23 (2012) (Review)

      Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.

      SKU: A0564 Category: API's & Intermediates
      • Additional information

      Additional information

      Synonyms

      4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride, Carticaine chlorhydrate, Carticaine hydrochloride, HOE 045, HOE 40045, Ultracaine

      Purity

      ≥98% (HPLC)

      Appearance

      White to beige powder

      CAS-Number

      23964-57-0

      Molecular Formula

      C13H20N2O3S . HCl

      Molecular Weight

      320.84

      Identity

      1H-NMR

      Solvents

      water (20 mg/ml), DMSO (15mg/ml), ethanol (5mg/ml).

      Smiles

      CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl

      InChi Key

      GDWDBGSWGNEMGJ-UHFFFAOYSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Hazard statements

      H315-H319-H335

      Precautionary statements

      P305 + P351 + P338

      GHS Symbol

      GHS07

      Signal word

      Warning

      Transportation

      Not dangerous goods

      References

      (1) S.F. Malamed, et al., J. Am. Dent. Assoc. 131, 635 (2000), (2) G.K. Wang, et al., J. Membr. Biol. 229, 1 (2009), (3) M. Snoeck, Local Reg. Anesth. 5, 23 (2012) (Review)

      Quantity

      500 mg, Bulk

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