Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to beige powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (20 mg/ml), DMSO (15mg/ml), ethanol (5mg/ml).
Available from stock
Articaine hydrochloride
- SKU
- A0564
Category: API's & Intermediates
- Synonyms
- 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride , Carticaine chlorhydrate , Carticaine hydrochloride , HOE 045 , HOE 40045 , Ultracaine
- 23964-57-0
- CAS-Number
- C13H20N2O3S . HCl
- Molecular Formula
- 320.84
- Molecular Weight
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- -20°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P305 + P351 + P338
- GHS Symbol
- GHS07
- Signal word
- Warning
- Transportation
- Not dangerous goods
- Description
- Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
- Smiles
- CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl
- InChi Key
- GDWDBGSWGNEMGJ-UHFFFAOYSA-N
- References
- (1) S.F. Malamed, et al., J. Am. Dent. Assoc. 131, 635 (2000) , (2) G.K. Wang, et al., J. Membr. Biol. 229, 1 (2009) , (3) M. Snoeck, Local Reg. Anesth. 5, 23 (2012) (Review)
Articaine is an amide local anesthetic widely used in dentistry. It possesses a unique ester side chain that is metabolized rapidly by circulating esterases. Articaine blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, similar to other local anesthetics. Binding of articaine to the sodium channel reduces sodium influx so that the threshold potential will not be reached and impulse conduction stops. The blocking action of articaine on the sodium channel is state dependent.
Additional information
| Synonyms | 4-Methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester hydrochloride, Carticaine chlorhydrate, Carticaine hydrochloride, HOE 045, HOE 40045, Ultracaine |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to beige powder |
| CAS-Number | 23964-57-0 |
| Molecular Formula | C13H20N2O3S . HCl |
| Molecular Weight | 320.84 |
| Identity | 1H-NMR |
| Solvents | water (20 mg/ml), DMSO (15mg/ml), ethanol (5mg/ml). |
| Smiles | CC1=CSC(C(OC)=O)=C1NC(C(NCCC)C)=O.Cl |
| InChi Key | GDWDBGSWGNEMGJ-UHFFFAOYSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305 + P351 + P338 |
| GHS Symbol | GHS07 |
| Signal word | Warning |
| Transportation | Not dangerous goods |
| References | (1) S.F. Malamed, et al., J. Am. Dent. Assoc. 131, 635 (2000), (2) G.K. Wang, et al., J. Membr. Biol. 229, 1 (2009), (3) M. Snoeck, Local Reg. Anesth. 5, 23 (2012) (Review) |
| Quantity | 500 mg, Bulk |
