Specifications
- Purity
- ≥98% (HPLC)
- Identity
- 1H-NMR
- Appearance
- White to beige powder
Properties
- Solvents
- DMSO (30mg/ml), water or ethanol (insoluble)
Available from stock
Brinzolamide
- SKU
- B0424
Category: API's & Intermediates
- Synonyms
- (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide , AL 4862 , Azopt
- 138890-62-7
- CAS-Number
- C12H21N3O5S3
- Molecular Formula
- 383.51
- Molecular Weight
- Short Term Storage
- -20°C
- Use / Stability
- Stable for at least 2 years after receipt when stored at -20°C.
- Handling Advice
- Protect from light and moisture.
- Long Term Storage
- -20°C
- Shipping
- AMBIENT
- Transportation
- Not dangerous goods
- Description
- Brinzolamide is a potent inhibitor of carbonic anhydrases (IC50=3.2nM and 45.3nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.
- References
- (1) T. Stams, et al., Protein Science 7, 556 (1998) , (2) P.A. Boriack-Sjodin, et al., Protein Science 7, 2483 (1998) , (3) C.J. Ingram & R.F. Brubaker, Am. J. Ophthalmol. 128, 292 (1999) , (4) G.E. Barnes, et al., Survey of Ophthalmol. 44, S131 (2012) , (5) H. Zheng & B. Lou, Acta Crystallogr. E Crystallogr. Commun. 72, 692 (2016) , (6) T. Nakano, et al., Adv. Ther. 33, 1452 (2016) , (7) Y.R. Dong, et al., Int. J. Ophthalmol. 11, 719 (2018)
- InChi Key
- HCRKCZRJWPKOAR-JTQLQIEISA-N
- Smiles
- O=S(C1=CC2=C(S1)S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O
Brinzolamide is a potent inhibitor of carbonic anhydrases (IC50=3.2nM and 45.3nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.
Additional information
| Synonyms | (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide, AL 4862, Azopt |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to beige powder |
| CAS-Number | 138890-62-7 |
| Molecular Formula | C12H21N3O5S3 |
| Molecular Weight | 383.51 |
| Identity | 1H-NMR |
| Solvents | DMSO (30mg/ml), water or ethanol (insoluble) |
| Smiles | O=S(C1=CC2=C(S1)S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O |
| InChi Key | HCRKCZRJWPKOAR-JTQLQIEISA-N |
| Shipping | AMBIENT |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Transportation | Not dangerous goods |
| References | (1) T. Stams, et al., Protein Science 7, 556 (1998), (2) P.A. Boriack-Sjodin, et al., Protein Science 7, 2483 (1998), (3) C.J. Ingram & R.F. Brubaker, Am. J. Ophthalmol. 128, 292 (1999), (4) G.E. Barnes, et al., Survey of Ophthalmol. 44, S131 (2012), (5) H. Zheng & B. Lou, Acta Crystallogr. E Crystallogr. Commun. 72, 692 (2016), (6) T. Nakano, et al., Adv. Ther. 33, 1452 (2016), (7) Y.R. Dong, et al., Int. J. Ophthalmol. 11, 719 (2018) |
| Quantity | 10 mg, 50 mg, Bulk |
