Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), methanol (1 mg/ml)
Category: Phytochemicals
Corosolic acid is a triterpene phytochemical found in medicinal herbal extracts. It possesses antiatherosclerotic, antihyperlipidemic/antidiabetic, antioxidant, anti-inflammatory, antifungal, antiviral and antitumor activities. It is an apoptotic agent that induces caspase-8, -9 and -3 activation and shows antiproliferative effects against cancer cell lines. It stimulates glucose uptake via enhancing insulin receptor phosphorylation and ameliorates obesity in vivo. It has been shown to exhibit antiangiogenic and antilymphangiogenic effects in vitor and in vivo. Has also been shown to inhibit mitochondrial fission and NOX2 expression preventing NLRP3 inflammasome activation. It inhibits adipose tissue inflammation and ameliorate insulin resistance via AMPK activation and is an α,-glucosidase inhibitor.
Synonyms | (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid, 2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 4547-24-4 |
Molecular Formula | C30H48O4 |
Molecular Weight | 472.70 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), methanol (1 mg/ml) |
Smiles | CC1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)C(O)C[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])[C@H]1C |
InChi Key | HFGSQOYIOKBQOW-LNGPDNCPSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) K.S Ahn, et al., Planta Med. 64, 468 (1998), (2) T. Miura, et al., Biol. Pharm. Bull. 29, 585 (2006), (3) L. Shi, et al., Eur. J. Pharmacol. 584, 21 (2008), (4) K. Yamada, et al., Biol. Pharm. Bull. 31, 651 (2008), (5) Y. Xu, et al., Cancer Lett. 284, 229 (2009), (6) H. Horlad, et al., Mol. Nutr. Food Res. 57, 1046 (2013), (7) K.H. Yoo, et al., Phytother. Res. 29, 714 (2015), (8) S.J. Kim, et al., BMB Rep. 49, 276 (2016), (9) Y. Li, et al., Antioxid. Redox Signal. 24, 893 (2016), (10) J. Yang, et al., Phytomedicine 23, 181 (2016), (11) M. Ni, et al., J. Sci. Food Agric. 99, 5881 (2019) |
InChi | InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17?,18-,20?,21-,22+,23-,24-,27-,28+,29+,30-/m0/s1 |
Quantity | 10 mg, 50 mg, Bulk |