Available from stock

Cycloastragenol

SKU: C0592

Category: Phytochemicals

Synonyms: Astramembrangenin , Cyclogalegigenin , Cyclosieversigenin , Cyclosiversigenin , GRN510 , TAT2; 84605-18-5
CAS-Number: C₃₀H₅₀O₅
Molecular Formula: 490.73
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: DMSO (10 mg/ml), ethanol (3 mg/ml), DMF (10 mg/ml)

Shipping: AMBIENT
Short Term Storage: -20°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases.
Smiles: O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O)[C@@]4([H])C(C)(C)[C@@H](O)CC[C@]45[C@]3(C5)CC[C@]2(C)[C@H]1[C@]6(C)O[C@H](C(C)(O)C)CC6
InChi Key: WENNXORDXYGDTP-UOUCMYEWSA-N
References: (1) S.R. Fauce, et al., J. Immunol. 181, 7400 (2008) , (2) J. Zhu, et al., Drug Metab. Pharmacokinet. 25, 477 (2010) , (3) F.C. Ip, et al., Neurosignals 22, 52 (2014) , (4) S. Wang, et al., BBRC 450, 306 (2014) , (5) Y. Zhao, et al., J. Ethnopharmacol. 169, 210 (2015) , (6) Y. Wan, et al., Eur. J. Pharmacol. 833, 545 (2018) , (7) Y. Yu, et al., Exp. Ther. Med. 16, 2175 (2018) , (8) G. Deng, et al., Int. Immunopharmacol. 74, 105682 (2019) , (9) Y. Cao, et al., Biomed. Res. Int. 2019, 7023950 (2019)
InChi: InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1

Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases.

SKU: C0592 Category: Phytochemicals

Additional information

Additional information

Synonyms	Astramembrangenin, Cyclogalegigenin, Cyclosieversigenin, Cyclosiversigenin, GRN510, TAT2
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	84605-18-5
Molecular Formula	C30H50O5
Molecular Weight	490.73
Identity	1H-NMR
Solvents	DMSO (10 mg/ml), ethanol (3 mg/ml), DMF (10 mg/ml)
Smiles	O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O)[C@@]4([H])C(C)(C)[C@@H](O)CC[C@]45[C@]3(C5)CC[C@]2(C)[C@H]1[C@]6(C)O[C@H](C(C)(O)C)CC6
InChi Key	WENNXORDXYGDTP-UOUCMYEWSA-N
Shipping	AMBIENT
Short Term Storage	-20°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) S.R. Fauce, et al., J. Immunol. 181, 7400 (2008), (2) J. Zhu, et al., Drug Metab. Pharmacokinet. 25, 477 (2010), (3) F.C. Ip, et al., Neurosignals 22, 52 (2014), (4) S. Wang, et al., BBRC 450, 306 (2014), (5) Y. Zhao, et al., J. Ethnopharmacol. 169, 210 (2015), (6) Y. Wan, et al., Eur. J. Pharmacol. 833, 545 (2018), (7) Y. Yu, et al., Exp. Ther. Med. 16, 2175 (2018), (8) G. Deng, et al., Int. Immunopharmacol. 74, 105682 (2019), (9) Y. Cao, et al., Biomed. Res. Int. 2019, 7023950 (2019)
InChi	InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1
Quantity	50 mg, 100 mg, Bulk