Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (10 mg/ml), ethanol (3 mg/ml), DMF (10 mg/ml)
Category: Phytochemicals
Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species. Extensive pharmacological effects have been attributed to cycloastragenol, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties, improvement of lipid metabolism and wound repair promotion. It has been shown to inhibit endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and NLRP3 inflammasome-mediated pyroptosis. It improved immune function in CD8+ T lymphocytes from HIV-1-infected patients. It might be a novel candidate for age-associated diseases.
Synonyms | Astramembrangenin, Cyclogalegigenin, Cyclosieversigenin, Cyclosiversigenin, GRN510, TAT2 |
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Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 84605-18-5 |
Molecular Formula | C30H50O5 |
Molecular Weight | 490.73 |
Identity | 1H-NMR |
Solvents | DMSO (10 mg/ml), ethanol (3 mg/ml), DMF (10 mg/ml) |
Smiles | O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O)[C@@]4([H])C(C)(C)[C@@H](O)CC[C@]45[C@]3(C5)CC[C@]2(C)[C@H]1[C@]6(C)O[C@H](C(C)(O)C)CC6 |
InChi Key | WENNXORDXYGDTP-UOUCMYEWSA-N |
Shipping | AMBIENT |
Short Term Storage | -20°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) S.R. Fauce, et al., J. Immunol. 181, 7400 (2008), (2) J. Zhu, et al., Drug Metab. Pharmacokinet. 25, 477 (2010), (3) F.C. Ip, et al., Neurosignals 22, 52 (2014), (4) S. Wang, et al., BBRC 450, 306 (2014), (5) Y. Zhao, et al., J. Ethnopharmacol. 169, 210 (2015), (6) Y. Wan, et al., Eur. J. Pharmacol. 833, 545 (2018), (7) Y. Yu, et al., Exp. Ther. Med. 16, 2175 (2018), (8) G. Deng, et al., Int. Immunopharmacol. 74, 105682 (2019), (9) Y. Cao, et al., Biomed. Res. Int. 2019, 7023950 (2019) |
InChi | InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1 |
Quantity | 50 mg, 100 mg, Bulk |