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    L-Glutathione reduced

    Available from stock

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      L-Glutathione reduced

      SKU
      G0005

      Category: Amino Acids, Peptides, Proteins

      Synonyms
      γ-L-Glutamyl-L-cysteinyl-glycine , GSH
      70-18-8
      CAS-Number
      C10H17N3O6S
      Molecular Formula
      307.32
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (Titration)
      Appearance
      White crystalline powder
      Identity
      1H-NMR

      Properties

      Solvents
      water (50 mg/ml)
      Melting Point
      192-195 °C (lit.)
      Shipping
      AMBIENT
      Short Term Storage
      +4°C
      Long Term Storage
      -20°C
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at -20°C.
      Transportation
      Not dangerous goods
      Description
      Major tripeptide widely distributed in both plants and animals. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Regulates activity of the redox sensitive transcription factor NF-?B. Cytoprotective. Serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. Involved in amino acid transport and maintenance of protein sulfhydryl reduction status. Posseses several metabolic, regulatory and protective functions. Forms disulfide bonds with cysteine residues in proteins.
      Smiles
      OC([C@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)N)=O
      InChi Key
      RWSXRVCMGQZWBV-WDSKDSINSA-N
      References
      A. Pompella, et al., Biochem. Pharmacol. 66, 1499 (2003) , A. Pastore, et al., Clin. Chim. Acta. 333, 19 (2003) , A. Chatterjee, Nutrients 5, 525 (2013) , E.V. Kalinina, et al., Biochemistry 79, 1562 (2014) , K. Aquilano, et al., Front. Pharmacol. 5, 196 (2014) , P. Diaz-Vivancos, et al., Free Radic. Biol. Med. 89, 1154 (2015) , T. Homma & J. Fujii, Curr. Drug Metab. 16, 560 (2015)
      InChi
      InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

      Major tripeptide widely distributed in both plants and animals. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Regulates activity of the redox sensitive transcription factor NF-?B. Cytoprotective. Serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. Involved in amino acid transport and maintenance of protein sulfhydryl reduction status. Posseses several metabolic, regulatory and protective functions. Forms disulfide bonds with cysteine residues in proteins.

      SKU: G0005 Category: Amino Acids, Peptides, Proteins
      • Additional information

      Additional information

      Synonyms

      γ-L-Glutamyl-L-cysteinyl-glycine, GSH

      Purity

      ≥98% (Titration)

      Appearance

      White crystalline powder

      CAS-Number

      70-18-8

      Molecular Formula

      C10H17N3O6S

      Molecular Weight

      307.32

      Identity

      1H-NMR

      Solvents

      water (50 mg/ml)

      Melting Point

      192-195 °C (lit.)

      Smiles

      OC([C@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)N)=O

      InChi Key

      RWSXRVCMGQZWBV-WDSKDSINSA-N

      Shipping

      AMBIENT

      Short Term Storage

      +4°C

      Long Term Storage

      -20°C

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at -20°C.

      Transportation

      Not dangerous goods

      References

      A. Pompella, et al., Biochem. Pharmacol. 66, 1499 (2003), A. Pastore, et al., Clin. Chim. Acta. 333, 19 (2003), A. Chatterjee, Nutrients 5, 525 (2013), E.V. Kalinina, et al., Biochemistry 79, 1562 (2014), K. Aquilano, et al., Front. Pharmacol. 5, 196 (2014), P. Diaz-Vivancos, et al., Free Radic. Biol. Med. 89, 1154 (2015), T. Homma & J. Fujii, Curr. Drug Metab. 16, 560 (2015)

      InChi

      InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

      Quantity

      5 g, 25 g, Bulk

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