L-Glutathione reduced

SKU: G0005

Category: Amino Acids, Peptides, Proteins

Synonyms: γ-L-Glutamyl-L-cysteinyl-glycine , GSH; 70-18-8
CAS-Number: C₁₀H₁₇N₃O₆S
Molecular Formula: 307.32
Molecular Weight

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (Titration)
Identity: 1H-NMR
Appearance: White crystalline powder

Properties

Melting Point: 192-195 °C (lit.)
Solvents: water (50 mg/ml)

Short Term Storage: +4°C
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling Advice: Protect from light and moisture.
Long Term Storage: -20°C
Shipping: AMBIENT

Transportation: Not dangerous goods

Description: Major tripeptide widely distributed in both plants and animals. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Regulates activity of the redox sensitive transcription factor NF-?B. Cytoprotective. Serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. Involved in amino acid transport and maintenance of protein sulfhydryl reduction status. Posseses several metabolic, regulatory and protective functions. Forms disulfide bonds with cysteine residues in proteins.
InChi: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
References: A. Pompella, et al., Biochem. Pharmacol. 66, 1499 (2003) , A. Pastore, et al., Clin. Chim. Acta. 333, 19 (2003) , A. Chatterjee, Nutrients 5, 525 (2013) , E.V. Kalinina, et al., Biochemistry 79, 1562 (2014) , K. Aquilano, et al., Front. Pharmacol. 5, 196 (2014) , P. Diaz-Vivancos, et al., Free Radic. Biol. Med. 89, 1154 (2015) , T. Homma & J. Fujii, Curr. Drug Metab. 16, 560 (2015)
InChi Key: RWSXRVCMGQZWBV-WDSKDSINSA-N
Smiles: OC([C@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)N)=O

Major tripeptide widely distributed in both plants and animals. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Regulates activity of the redox sensitive transcription factor NF-?B. Cytoprotective. Serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. Involved in amino acid transport and maintenance of protein sulfhydryl reduction status. Posseses several metabolic, regulatory and protective functions. Forms disulfide bonds with cysteine residues in proteins.

SKU: G0005 Category: Amino Acids, Peptides, Proteins

Additional information

Additional information

Synonyms	γ-L-Glutamyl-L-cysteinyl-glycine, GSH
Purity	≥98% (Titration)
Appearance	White crystalline powder
CAS-Number	70-18-8
Molecular Formula	C10H17N3O6S
Molecular Weight	307.32
Identity	1H-NMR
Solvents	water (50 mg/ml)
Melting Point	192-195 °C (lit.)
Smiles	OC([C@H](CCC(N[C@@H](CS)C(NCC(O)=O)=O)=O)N)=O
InChi Key	RWSXRVCMGQZWBV-WDSKDSINSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	A. Pompella, et al., Biochem. Pharmacol. 66, 1499 (2003), A. Pastore, et al., Clin. Chim. Acta. 333, 19 (2003), A. Chatterjee, Nutrients 5, 525 (2013), E.V. Kalinina, et al., Biochemistry 79, 1562 (2014), K. Aquilano, et al., Front. Pharmacol. 5, 196 (2014), P. Diaz-Vivancos, et al., Free Radic. Biol. Med. 89, 1154 (2015), T. Homma & J. Fujii, Curr. Drug Metab. 16, 560 (2015)
InChi	InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
Quantity	5 g, 25 g, Bulk