Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- water (50 mg/ml), DMSO (2 mg/ml)
- Melting Point
- 159-161 °C (lit.)
Available from stock
D-Glucuronic acid
- SKU
- G0020
Category: Carbohydrates
- Synonyms
- Glucosiduronic acid , D-GlcA
- 6556-12-3
- CAS-Number
- C6H10O7
- Molecular Formula
- 194.14
- Molecular Weight
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
- Shipping
- AMBIENT
- Short Term Storage
- +4°C
- Long Term Storage
- +4°C
- Handling Advice
- Protect from light and moisture.
- Use / Stability
- Stable for at least 2 years after receipt when stored at +4°C.
- Transportation
- Not dangerous goods
- Description
- Glucuronic acid is a water soluble sugar acid formed by oxidation of the C-6 carbon of glucose. Glucuronic acid is a common building block of proteoglycans and glycoglycerolipids and a key intermediate metabolite of the uronic acid pathway. It can be used as a reference compound to quantify glucuronic acid in urine sample. It also has been shown to act on toll-like receptor 4 to aggravate both acute and chronic inflammatory conditions as well as increasing the perceived severity of pain in patients with chronic pain conditions, via up-regulation of the production and release of endogenous inflammatory signaling molecules within the body.
- Smiles
- O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1
- InChi Key
- AEMOLEFTQBMNLQ-QIUUJYRFSA-N
- References
- (1) J.J. Burns, et al., JPET 129, 132 (1960) , (2) T. Kishikawa, et al., Chem. Pharm. Bull. 14, 1354 (1966) , (3) U. Lindahl, et al., BBRC 46, 985 (1972) , (4) A.O. El-Nezhawy, et al., Arch. Pharm. 344, 648 (2011) , (5) A.O. El-Nezhawy, et al., Med. Chem. 7, 624 (2011) , (6) S.S. Lewis, et al., Brain Behav. Immun. 30, 24 (2013) , (7) S. Marasini, et al., J. Nanosci. Nanotechnol. 18, 6333 (2018)
- InChi
- InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1
Glucuronic acid is a water soluble sugar acid formed by oxidation of the C-6 carbon of glucose. Glucuronic acid is a common building block of proteoglycans and glycoglycerolipids and a key intermediate metabolite of the uronic acid pathway. It can be used as a reference compound to quantify glucuronic acid in urine sample. It also has been shown to act on toll-like receptor 4 to aggravate both acute and chronic inflammatory conditions as well as increasing the perceived severity of pain in patients with chronic pain conditions, via up-regulation of the production and release of endogenous inflammatory signaling molecules within the body.
Additional information
| Synonyms | Glucosiduronic acid, D-GlcA |
|---|---|
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white powder |
| CAS-Number | 6556-12-3 |
| Molecular Formula | C6H10O7 |
| Molecular Weight | 194.14 |
| Identity | 1H-NMR |
| Solvents | water (50 mg/ml), DMSO (2 mg/ml) |
| Melting Point | 159-161 °C (lit.) |
| Smiles | O=C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 |
| InChi Key | AEMOLEFTQBMNLQ-QIUUJYRFSA-N |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Transportation | Not dangerous goods |
| References | (1) J.J. Burns, et al., JPET 129, 132 (1960), (2) T. Kishikawa, et al., Chem. Pharm. Bull. 14, 1354 (1966), (3) U. Lindahl, et al., BBRC 46, 985 (1972), (4) A.O. El-Nezhawy, et al., Arch. Pharm. 344, 648 (2011), (5) A.O. El-Nezhawy, et al., Med. Chem. 7, 624 (2011), (6) S.S. Lewis, et al., Brain Behav. Immun. 30, 24 (2013), (7) S. Marasini, et al., J. Nanosci. Nanotechnol. 18, 6333 (2018) |
| InChi | InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1 |
| Quantity | 25 g, 50 g, Bulk |
