Available from stock

Ellagic acid

SKU: E0232

Category: Phytochemicals

Synonyms: 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone , Alizarin Yellow , Benzoaric acid , Elagostasine , Gallogen , Lagistase , TBBD; 476-66-4
CAS-Number: C₁₄H₆O₈
Molecular Formula: 302.19
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥95% (HPLC)
Appearance: Brown powder
Identity: 1H-NMR

Properties

Solvents: ethanol (slightly), DMSO (<1 mg/ml)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Transportation: Not dangerous goods

Description: Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark and peels. It has antioxidant, anticancer, neuroprotective, antimutagenic, anti-inflammatory and organ-preserving properties. It alters cytochrome P450 activity and improvea metabolism and clearance of xenobiotics, as well as altera immune function. Selective, ATP-competitive inhibitor of casein kinase 2 (CK2). Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity. It acts as a scavenger of oxygen species produced by hydrogen peroxide treatment and as a protector of the DNA double helix from alkylating agent injury. Also reported to inhibit topoisomerases I and II and gyrase and glutathione S-transferase.
Smiles: OC1=CC2=C3C(OC(C4=C3C(OC2=O)=C(O)C(O)=C4)=O)=C1O
InChi Key: AFSDNFLWKVMVRB-UHFFFAOYSA-N
References: (1) C.T. Allen, et al., Immunopharmacol. Immunotoxicol. 25, 409 (2003) , (2) G. Cozza, et al., J. Med. Chem. 49, 2363 (2006) , (3) D.H. Han, et al., Anticancer Res. 26, 3601 (2006) , (4) R. Hayeshi, et al., Food Chem. Toxicol. 45, 286 (2007) , (5) D. Heber, Cancer Lett. 269, 262 (2008) , (6) C. Bell & S. Hawthorne, J. Pharm. Pharmacol. 60, 139 (2008) (Review) , (7) B.R. Selvi, et al., J. Biol. Chem. 285, 7143 (2010) , (8) J. Paluszczak, et al., Toxicol. Lett. 192, 119 (2010) , (9) M.A. Lea, et al., Anticancer Res. 30, 311 (2010) , (10) H.M. Zhang, et al., Cancer Biol. Med. 11, 92 (2014) (Review) , (11) W.R. García-Nino & C. Zazueta, Pharmacol. Res. 97, 84 (2015) (Review) , (12) T. Ahmed, et al., Curr. Pharm. Des. 22, 1350 (2016) (Review) , (13) G. Derosa, et al., Adv. Exp. Med. Biol. 928, 4473 (Review) , (14) A. Zeb, Mol. Cell Biochem. 448, 27 (2018) (Review) , (15) C. Ceci, et al., Nutrients 10, E1756 (2018) , (16) S. Alfei, et al., Eur. J. Med. Chem. 183, 111724 (2019) (Review)
InChi: InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark and peels. It has antioxidant, anticancer, neuroprotective, antimutagenic, anti-inflammatory and organ-preserving properties. It alters cytochrome P450 activity and improvea metabolism and clearance of xenobiotics, as well as altera immune function. Selective, ATP-competitive inhibitor of casein kinase 2 (CK2). Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity. It acts as a scavenger of oxygen species produced by hydrogen peroxide treatment and as a protector of the DNA double helix from alkylating agent injury. Also reported to inhibit topoisomerases I and II and gyrase and glutathione S-transferase.

SKU: E0232 Category: Phytochemicals

Additional information

Additional information

Synonyms	4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone, Alizarin Yellow, Benzoaric acid, Elagostasine, Gallogen, Lagistase, TBBD
Purity	≥95% (HPLC)
Appearance	Brown powder
CAS-Number	476-66-4
Molecular Formula	C14H6O8
Molecular Weight	302.19
Identity	1H-NMR
Solvents	ethanol (slightly), DMSO (<1 mg/ml)
Smiles	OC1=CC2=C3C(OC(C4=C3C(OC2=O)=C(O)C(O)=C4)=O)=C1O
InChi Key	AFSDNFLWKVMVRB-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Transportation	Not dangerous goods
References	(1) C.T. Allen, et al., Immunopharmacol. Immunotoxicol. 25, 409 (2003), (2) G. Cozza, et al., J. Med. Chem. 49, 2363 (2006), (3) D.H. Han, et al., Anticancer Res. 26, 3601 (2006), (4) R. Hayeshi, et al., Food Chem. Toxicol. 45, 286 (2007), (5) D. Heber, Cancer Lett. 269, 262 (2008), (6) C. Bell & S. Hawthorne, J. Pharm. Pharmacol. 60, 139 (2008) (Review), (7) B.R. Selvi, et al., J. Biol. Chem. 285, 7143 (2010), (8) J. Paluszczak, et al., Toxicol. Lett. 192, 119 (2010), (9) M.A. Lea, et al., Anticancer Res. 30, 311 (2010), (10) H.M. Zhang, et al., Cancer Biol. Med. 11, 92 (2014) (Review), (11) W.R. García-Nino & C. Zazueta, Pharmacol. Res. 97, 84 (2015) (Review), (12) T. Ahmed, et al., Curr. Pharm. Des. 22, 1350 (2016) (Review), (13) G. Derosa, et al., Adv. Exp. Med. Biol. 928, 4473 (Review), (14) A. Zeb, Mol. Cell Biochem. 448, 27 (2018) (Review), (15) C. Ceci, et al., Nutrients 10, E1756 (2018), (16) S. Alfei, et al., Eur. J. Med. Chem. 183, 111724 (2019) (Review)
InChi	InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
Quantity	1 g, 5 g, 10 g, Bulk