Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO, DMF, ethanol
Category: Lipids, Fatty Acids
Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer’s disease symptoms and has also shown a number of antitumor effects.
Synonyms | Boforsin, Colforsin, Coleonol, NSC 357088, NSC 375489, HL 362, L 75-1362B |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 66575-29-9 |
Molecular Formula | C22H34O7 |
Molecular Weight | 410.5 |
Identity | 1H-NMR |
Solvents | DMSO, DMF, ethanol |
Smiles | C=C[C@](C1)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@@]2(O)C1=O |
InChi Key | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Transportation | Not dangerous goods |
References | (1) H. Metzger & E. Lindner, Arzneimittelforschung 31, 1248 (1981), (2) K.B. Seamon & J.W. Daly, J. Cyclic Nucleotide Res. 7, 201 (1981), (3) N.J. de Souza, et al., Med. Res. Rev. 3, 201 (1983), (4) H.G. Joost & H.J. Steinfelder, Mol. Pharmacol. 31, 279 (1987), (5) A. Laurenza, et al., TIPS 10, 442 (1989) (Review), (6) M.L. Aylwin & M.M. White, Mol. Pharmacol. 41, 908 (1992), (7) P.J. Scarpace & M. Matheny, Pflugers Arch. 431, 388 (1996), (8) P.A. Insel & R.S. Ostrom, Cell Mol. Neurobiol. 23, 305 (2003), (9) N. Canu, et al., J. Neurochem. 92, 1228 (2005), (10) H. Yamanaka, et al., Mol. Med. Rep. 3, 133 (2010), (11) R.H. Alasbahi & M.F. Melzig, Pharmazie 67, 5 (2012) (Review), (12) V.D. Wagh, et al., J. Postgrad. Med. 58, 199 (2012) (Review), (13) B.A. Owona, et al., J. Neuropathol. Exp. Neurol. 75, 618 (2016), (14) L. Sapio, et al., J. Cell Physiol. 232, 922 (2017) (Review) |
InChi | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
Quantity | 10 mg, 25 mg, 50 mg, Bulk |