Forskolin

Available from stock

Forskolin

SKU
F0167

Category:

Synonyms
Boforsin , Colforsin , Coleonol , NSC 357088 , NSC 375489 , HL 362 , L 75-1362B
66575-29-9
CAS-Number
C22H34O7
Molecular Formula
410.5
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Specifications

Purity
≥98% (HPLC)
Appearance
White to off-white powder
Identity
1H-NMR

Properties

Solvents
DMSO, DMF, ethanol
Shipping
AMBIENT
Short Term Storage
RT
Long Term Storage
RT
Handling Advice
Protect from light and moisture.
Use / Stability
Stable for at least 2 years after receipt when stored at RT.
Transportation
Not dangerous goods
Description
Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer’s disease symptoms and has also shown a number of antitumor effects.
Smiles
C=C[C@](C1)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@@]2(O)C1=O
InChi Key
OHCQJHSOBUTRHG-KGGHGJDLSA-N
References
(1) H. Metzger & E. Lindner, Arzneimittelforschung 31, 1248 (1981) , (2) K.B. Seamon & J.W. Daly, J. Cyclic Nucleotide Res. 7, 201 (1981) , (3) N.J. de Souza, et al., Med. Res. Rev. 3, 201 (1983) , (4) H.G. Joost & H.J. Steinfelder, Mol. Pharmacol. 31, 279 (1987) , (5) A. Laurenza, et al., TIPS 10, 442 (1989) (Review) , (6) M.L. Aylwin & M.M. White, Mol. Pharmacol. 41, 908 (1992) , (7) P.J. Scarpace & M. Matheny, Pflugers Arch. 431, 388 (1996) , (8) P.A. Insel & R.S. Ostrom, Cell Mol. Neurobiol. 23, 305 (2003) , (9) N. Canu, et al., J. Neurochem. 92, 1228 (2005) , (10) H. Yamanaka, et al., Mol. Med. Rep. 3, 133 (2010) , (11) R.H. Alasbahi & M.F. Melzig, Pharmazie 67, 5 (2012) (Review) , (12) V.D. Wagh, et al., J. Postgrad. Med. 58, 199 (2012) (Review) , (13) B.A. Owona, et al., J. Neuropathol. Exp. Neurol. 75, 618 (2016) , (14) L. Sapio, et al., J. Cell Physiol. 232, 922 (2017) (Review)
InChi
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

Forskolin is a naturally occurring diterpene. It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP (an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals) in a wide variety of intact cells and tissue preparations. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling. Forskolin is a smooth muscle relaxant/vasodilator with inotropic and antihypertensive activity. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. It has anti-neuroinflammatory and neuroprotective properties that ameliorates Alzheimer’s disease symptoms and has also shown a number of antitumor effects.

SKU: F0167 Category:

Additional information

Synonyms

Boforsin, Colforsin, Coleonol, NSC 357088, NSC 375489, HL 362, L 75-1362B
Purity

≥98% (HPLC)
Appearance

White to off-white powder
CAS-Number

66575-29-9
Molecular Formula

C22H34O7
Molecular Weight

410.5
Identity

1H-NMR
Solvents

DMSO, DMF, ethanol
Smiles

C=C[C@](C1)(C)O[C@]2(C)[C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@@]2(O)C1=O
InChi Key

OHCQJHSOBUTRHG-KGGHGJDLSA-N
Shipping

AMBIENT
Short Term Storage

RT
Long Term Storage

RT
Handling Advice

Protect from light and moisture.
Use / Stability

Stable for at least 2 years after receipt when stored at RT.
Transportation

Not dangerous goods
References

(1) H. Metzger & E. Lindner, Arzneimittelforschung 31, 1248 (1981), (2) K.B. Seamon & J.W. Daly, J. Cyclic Nucleotide Res. 7, 201 (1981), (3) N.J. de Souza, et al., Med. Res. Rev. 3, 201 (1983), (4) H.G. Joost & H.J. Steinfelder, Mol. Pharmacol. 31, 279 (1987), (5) A. Laurenza, et al., TIPS 10, 442 (1989) (Review), (6) M.L. Aylwin & M.M. White, Mol. Pharmacol. 41, 908 (1992), (7) P.J. Scarpace & M. Matheny, Pflugers Arch. 431, 388 (1996), (8) P.A. Insel & R.S. Ostrom, Cell Mol. Neurobiol. 23, 305 (2003), (9) N. Canu, et al., J. Neurochem. 92, 1228 (2005), (10) H. Yamanaka, et al., Mol. Med. Rep. 3, 133 (2010), (11) R.H. Alasbahi & M.F. Melzig, Pharmazie 67, 5 (2012) (Review), (12) V.D. Wagh, et al., J. Postgrad. Med. 58, 199 (2012) (Review), (13) B.A. Owona, et al., J. Neuropathol. Exp. Neurol. 75, 618 (2016), (14) L. Sapio, et al., J. Cell Physiol. 232, 922 (2017) (Review)
InChi

InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
Quantity

10 mg, 25 mg, 50 mg, Bulk

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