Available from stock

Formaldehyde-2,4-DNPH

SKU: F0382

Category: Amino Acids, Peptides, Proteins

Synonyms: Formaldehyde-2,4-dinitrophenylhydrazone; 1081-15-8
CAS-Number: C₇H₆N₄O₄
Molecular Formula: 210.15
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: Light yellow to yellow powder
Identity: 1H-NMR

Properties

Solvents: Soluble in DMSO.
Melting Point: 153-156 °C (lit.)

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: RT
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at RT.

Hazard statements: H315 - H319 - H335
Precautionary statements: P261 - P305 + P351 + P338
GHS Symbol: GHS07
Signal word: Warning
Transportation: Not dangerous goods

Description: Guanosine 5'-triphosphate (GTP) trisodium salt activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. It also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. GTP is involved in the initiation of peptide synthesis during the binding of formylmethionyl-tRNA (F-met-tRNA) to the ribosome. It is also involved in polypeptide chain elongation. GTP is hydrolyzed by tubulin and its hydrolysis is accompanied by microtubule assembly. Guanosine 5'-triphosphate trisodium salt up-regulates miRNA (specifically miR133a and miR133b) and myogenic regulator factor and induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules (mainly guanosine) in the extracellular milieu.
Smiles: C=NNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O
InChi Key: UEQLSLWCHGLSML-UHFFFAOYSA-N
References: (1) Y. Kaziro; Biochim. Biophys. Acta 505, 95 (1978) (Review) , (2) M.F. Carlier; Mol. Cell Biochem. 47, 97 (1982) (Review) , (3) M.L. Pall; Curr. Top. Cell Regul. 25, 1 (1985) (Review) , (4) F. McCormick; Curr. Opin. Cell Biol. 2, 181 (1990) (Review) , (5) J.C. Lacal; FEBS Lett. 410, 73 (1997) , (6) J.S. Gutkind; Oncogene 17, 1331 (1998) , (7) N. Dhanasekaran, et al.; Oncogene 17, 1383 (1998) , (8) F. Schimmoller, et al.; J. Biol. Chem. 273, 22161 (1998) , (9) J. Gomez, et al.; Immunol. Cell Biol. 76, 125 (1998) , (10) P. Woodman; Curr. Biol. 8, R199 (1998) , (11) U.G. Knaus; Immunol. Res. 21, 103 (2000) (Review) , (12) F. Blombach, et al.; Biochem. Soc. Trans. 39, 45 (2011) , (13) O. Haller, et al.; J. Interf. Cytokine Res. 31, 79 (2011) , (14) D. Benjamin & M.N. Hall; Cell Rep. 19, 2643 (2017) (Review) , (15) A. Kowluru; Small GTPases 12, 323 (2021) (Review)
InChi: (1) S. Landaas & E. Solem: Scand. J. Clin. Lab. Invest. 43, 95 (1983) , (2) F. Podebrad, et al.: Clin. Chim. Acta 292, 93 (2000) , (3) A.B. Van Kuilenburg, et al.: Biochem. J. 379, 119 (2004)

Guanosine 5′-triphosphate (GTP) trisodium salt activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. It also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. GTP is involved in the initiation of peptide synthesis during the binding of formylmethionyl-tRNA (F-met-tRNA) to the ribosome. It is also involved in polypeptide chain elongation. GTP is hydrolyzed by tubulin and its hydrolysis is accompanied by microtubule assembly. Guanosine 5′-triphosphate trisodium salt up-regulates miRNA (specifically miR133a and miR133b) and myogenic regulator factor and induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules (mainly guanosine) in the extracellular milieu.

SKU: F0382 Category: Amino Acids, Peptides, Proteins

Additional information

Additional information

Synonyms	Formaldehyde-2,4-dinitrophenylhydrazone
Purity	≥98% (HPLC)
Appearance	Light yellow to yellow powder
CAS-Number	1081-15-8
Molecular Formula	C7H6N4O4
Molecular Weight	210.15
Identity	1H-NMR
Solvents	Soluble in DMSO.
Melting Point	153-156 °C (lit.)
Smiles	C=NNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O
InChi Key	UEQLSLWCHGLSML-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	RT
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at RT.
Hazard statements	H315 – H319 – H335
Precautionary statements	P261 – P305 + P351 + P338
GHS Symbol	GHS07
Signal word	Warning
Transportation	Not dangerous goods
References	(1) Y. Kaziro; Biochim. Biophys. Acta 505, 95 (1978) (Review), (2) M.F. Carlier; Mol. Cell Biochem. 47, 97 (1982) (Review), (3) M.L. Pall; Curr. Top. Cell Regul. 25, 1 (1985) (Review), (4) F. McCormick; Curr. Opin. Cell Biol. 2, 181 (1990) (Review), (5) J.C. Lacal; FEBS Lett. 410, 73 (1997), (6) J.S. Gutkind; Oncogene 17, 1331 (1998), (7) N. Dhanasekaran, et al.; Oncogene 17, 1383 (1998), (8) F. Schimmoller, et al.; J. Biol. Chem. 273, 22161 (1998), (9) J. Gomez, et al.; Immunol. Cell Biol. 76, 125 (1998), (10) P. Woodman; Curr. Biol. 8, R199 (1998), (11) U.G. Knaus; Immunol. Res. 21, 103 (2000) (Review), (12) F. Blombach, et al.; Biochem. Soc. Trans. 39, 45 (2011), (13) O. Haller, et al.; J. Interf. Cytokine Res. 31, 79 (2011), (14) D. Benjamin & M.N. Hall; Cell Rep. 19, 2643 (2017) (Review), (15) A. Kowluru; Small GTPases 12, 323 (2021) (Review)
InChi	(1) S. Landaas & E. Solem: Scand. J. Clin. Lab. Invest. 43, 95 (1983), (2) F. Podebrad, et al.: Clin. Chim. Acta 292, 93 (2000), (3) A.B. Van Kuilenburg, et al.: Biochem. J. 379, 119 (2004)
Quantity	10 mg, Bulk