Specifications
- Purity
- ≥99% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in water (50 mg/ml).
Category: Non Fluorescent Detection & Chromogene Detection
Naphthol AS-TR Phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS-TR Phosphate is converted to naphthol AS-TR displaying excitation/emission spectra of 388/512nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting and dot blot applications. Naphthol AS-TR Phosphate is a cyclic-AMP response element-binding protein (CREB)-CREB binding protein (CBP) transcription factor complex inhibitor and a potential therapeutic agent for lung cancer.
Synonyms | N-(4-chloro-2-methylphenyl)-3-(phosphonooxy)-2-Naphthalenecarboxamide, NASTRp |
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Purity | ≥99% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 4264-93-1 |
Molecular Formula | C18H13CINNa2O5P |
Molecular Weight | 435.71 |
Identity | 1H-NMR |
Solvents | Soluble in water (50 mg/ml). |
Smiles | O=C(NC1=C(C)C=C(Cl)C=C1)C2=CC3=CC=CC=C3C=C2OP(O[Na])(O[Na])=O |
InChi Key | TYCHZTPSWMGRRI-UHFFFAOYSA-L |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Very hygroscopic. Store under inert gas. |
Use / Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Transportation | Not dangerous goods |
References | (1) Z. Lojda, etal., Histochemie 11, 13 (1967), (2) G.G. Guilbault & A. Vaughan, Anal. Lett. 3, 1 (1970), (3) A. Vaughan, et al., Anal. Chem. 43, 721 (1971), (4) A.S.H.De Jong, et al., Histochem. J. 17, 1119 (1985), (5) R. Hong, et al., Anal. Chem. 86, 1459 (2014), (6) J.W. Lee, et al., PLoS One 10, e0122628 (2015) |
Quantity | 1 g, 5 g, Bulk |