Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White crystalline solid
- Identity
- 1H-NMR
Properties
- Solvents
- Soluble in water (30mg/ml) or DMSO (30mg/ml).
Category: API's & Intermediates
Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Pravastatin reduces LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Pravastatin also acts as an immunomodulator and as an inhibitor of p21ras isoprenylation.
Synonyms | Eptastatin sodium salt hydrate, 3&beta,-Hydroxycompactin, Mevalothin |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White crystalline solid |
CAS-Number | 81131-70-6 |
Molecular Formula | C23H35O7Na · xH2O |
Molecular Weight | 446.51 (anhydrous basis) |
Identity | 1H-NMR |
Solvents | Soluble in water (30mg/ml) or DMSO (30mg/ml). |
Smiles | O[C@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@](O)([H])C[C@H](O)CC(O[Na])=O)=C1 |
InChi Key | VWBQYTRBTXKKOG-BAWPFLGFSA-M |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) T. Koga, et al., Biochim. Biophys. Acta 1045, 115 (1990), (2) S.M. Singhvi, et al., Br. J. Clin. Pharmacol. 29, 239 (1990), (3) A. Corsini, et al., Pharmacol. Res. 31, 9 (1995), (4) B.A. Hamelin & J. Turgeon, Trends Pharmacol. Sci. 19, 26 (1998), (5) M. Tatsuta, et al., Br. J. Cancer 77, 581 (1998), (6) W.H. Kaesemeyer, et al., J. Am. Coll. Cardiol. 33, 234 (1999), (7) B. Kwak, et al., Nat Med. 6, 1399 (2000), (8) J.A. Tobert, Nat. Rev. Drug Discov. 2, 517 (2003), (9) A.A. Al-Badr, et al., Prof. Drug Subst. Excip. Rel. Methodol. 39, 433 (2014) |
Quantity | 50 mg, Bulk |