Available from stock

Pravastatin sodium

SKU: P0933

Category: API's & Intermediates

Synonyms: Eptastatin sodium salt hydrate, 3&beta,-Hydroxycompactin, Mevalothin; 81131-70-6
CAS-Number: C₂₃H₃₅O₇Na · xH₂O
Molecular Formula: 446.51 (anhydrous basis)
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White crystalline solid
Identity: 1H-NMR

Properties

Solvents: Soluble in water (30mg/ml) or DMSO (30mg/ml).

Shipping: AMBIENT
Short Term Storage: RT
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Transportation: Not dangerous goods

Description: Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Pravastatin reduces LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Pravastatin also acts as an immunomodulator and as an inhibitor of p21ras isoprenylation.
Smiles: O[C@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@](O)([H])C[C@H](O)CC(O[Na])=O)=C1
InChi Key: VWBQYTRBTXKKOG-BAWPFLGFSA-M
References: (1) T. Koga, et al., Biochim. Biophys. Acta 1045, 115 (1990) , (2) S.M. Singhvi, et al., Br. J. Clin. Pharmacol. 29, 239 (1990) , (3) A. Corsini, et al., Pharmacol. Res. 31, 9 (1995) , (4) B.A. Hamelin & J. Turgeon, Trends Pharmacol. Sci. 19, 26 (1998) , (5) M. Tatsuta, et al., Br. J. Cancer 77, 581 (1998) , (6) W.H. Kaesemeyer, et al., J. Am. Coll. Cardiol. 33, 234 (1999) , (7) B. Kwak, et al., Nat Med. 6, 1399 (2000) , (8) J.A. Tobert, Nat. Rev. Drug Discov. 2, 517 (2003) , (9) A.A. Al-Badr, et al., Prof. Drug Subst. Excip. Rel. Methodol. 39, 433 (2014)

Pravastatin is a water-soluble, orally effective, competitive inhibitor of Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Ki = 2.3nM), the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering/regulating compounds. Pravastatin potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties. Pravastatin reduces LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. Pravastatin also acts as an immunomodulator and as an inhibitor of p21ras isoprenylation.

SKU: P0933 Category: API's & Intermediates

Additional information

Additional information

Synonyms	Eptastatin sodium salt hydrate, 3&beta,-Hydroxycompactin, Mevalothin
Purity	≥98% (HPLC)
Appearance	White crystalline solid
CAS-Number	81131-70-6
Molecular Formula	C23H35O7Na · xH2O
Molecular Weight	446.51 (anhydrous basis)
Identity	1H-NMR
Solvents	Soluble in water (30mg/ml) or DMSO (30mg/ml).
Smiles	O[C@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@](O)([H])C[C@H](O)CC(O[Na])=O)=C1
InChi Key	VWBQYTRBTXKKOG-BAWPFLGFSA-M
Shipping	AMBIENT
Short Term Storage	RT
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Transportation	Not dangerous goods
References	(1) T. Koga, et al., Biochim. Biophys. Acta 1045, 115 (1990), (2) S.M. Singhvi, et al., Br. J. Clin. Pharmacol. 29, 239 (1990), (3) A. Corsini, et al., Pharmacol. Res. 31, 9 (1995), (4) B.A. Hamelin & J. Turgeon, Trends Pharmacol. Sci. 19, 26 (1998), (5) M. Tatsuta, et al., Br. J. Cancer 77, 581 (1998), (6) W.H. Kaesemeyer, et al., J. Am. Coll. Cardiol. 33, 234 (1999), (7) B. Kwak, et al., Nat Med. 6, 1399 (2000), (8) J.A. Tobert, Nat. Rev. Drug Discov. 2, 517 (2003), (9) A.A. Al-Badr, et al., Prof. Drug Subst. Excip. Rel. Methodol. 39, 433 (2014)
Quantity	50 mg, Bulk