Specifications
- Purity
- ≥99% (Titr.)
- Appearance
- White to off-white solid
- Optical Activity
- -245 ° to - 258°
Properties
- Solvents
- Soluble in water (10mg/ml).
- Melting Point
- 115 - 116 °C
Category: Antibiotics
Quinine hydrochloride dihydrate is isolated from the cinchona tree′s bark, is characterized by a bitter taste and shows antipyretic (fever-reducing), anti-malarial, analgesic (painkilling), anti-viral and anti-inflammatory properties properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase (MAO), an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers. Because of its relatively constant and well-known fluorescence quantum yield, quinine sulfate is used in photochemistry as a popular and common fluorescence standard.
Synonyms | (8α, 9R)-6'-Methoxycinchonan-9-ol monohydrochloride dihydrate |
---|---|
Purity | ≥99% (Titr.) |
Appearance | White to off-white solid |
CAS-Number | 6119-47-7 |
Molecular Formula | C20H24N2O2 · HCl · 2H2O |
Molecular Weight | 396.91 |
Solvents | Soluble in water (10mg/ml). |
Melting Point | 115 – 116 °C |
Smiles | O[C@H](C1=C(C=C(OC)C=C2)C2=NC=C1)[C@H]3[N@](C[C@@H]4C=C)CC[C@H]4C3.Cl |
InChi Key | LBSFSRMTJJPTCW-DSXUQNDKSA-N |
Shipping | AMBIENT |
Short Term Storage | RT |
Long Term Storage | RT |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at RT. |
Hazard statements | H302 – H317 – H334 |
Precautionary statements | P261 – P264 – P270 – P280 – P301 + P312 – P302 + P352 |
GHS Symbol | GHS07+GHS08 |
Signal word | Danger |
Transportation | Not dangerous goods |
References | (1) K.A. Conklin & S.C. Chou, Science 170, 1213 (1970), (2) D.F. Eaton, Pure Appl. Chem. 60, 1107 (1988), (3) N. Mitsui, et al., Chem. Pharm. Bull. 37, 363 (1989), (4) M. Maki, et al., Biomed. Res. 30, 137 (2009), (5) J. Achan, et al., Malar. J. 10, 144 (2011), (6) F. Islahudin, et al., Sci. Rep. 4, 3618 (2014), (7) S. Malakar, et al., Virus Res. 255, 171 (2018), (8) Y. Guo, et al., Luminescence 34, 450 (2019), (9) K. Nawara & J. Waluk, Anal. Chem. 91, 5389 (2019), (10) L.G. Leanse, et al., J. Infect. Dis. 221, 618 (2020), (11) U.G. Chandrika & U. Karunarathna, Feat. Assessm. Pain Anaesth. Analg. Chaper 5, 47 (2022) |
Quantity | 10 g, 50 g, 100 g, Bulk |
cdx-Optical Activity | -245 ° to – 258° |