Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- Beige to light brown powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (5 mg/ml), DMF (3 mg/ml), pyridine (50 mg/ml)
Downloads
- Safety Data Sheet
- CDX H0245 MSDS.pdf
Category: Phytochemicals
Hesperidin is a flavanone rutinoside first isolated from citrus peels. It is metabolized by intestinal bacteria to an aglycone form, hesperetin, which is thought to be more bioavailable due to reduced polarity that allows for increased cell permeability. Both hesperidin (Hsd) and its aglycone hesperetin (Hst) have various biological properties. Studies have shown both anti-cancer and cancer chemopreventive effects, associated with their antioxidant, radical scavenging and anti-inflammatory activities. In addition, Hsd and Hst interfere at different stages of cancer. They inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, Bcl-2 and Bax for the induction of apoptosis, and COX-2, MMP-2 and MMP-9 for the inhibition of angiogenesis and metastasis. They also have show cardioprotective, neuroprotective and antimicrobial effects.
Synonyms | Cirantin, Hesperidoside, NSC 44184, Hesperetin 7-rhamnoglucoside, Hesperitin-7-rutinoside, Diosmin EP Impurity B |
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Purity | ≥98% (HPLC) |
Appearance | Beige to light brown powder |
CAS-Number | 520-26-3 |
Molecular Formula | C28H34O15 |
Molecular Weight | 610.56 |
Identity | 1H-NMR |
Solvents | DMSO (5 mg/ml), DMF (3 mg/ml), pyridine (50 mg/ml) |
Smiles | O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4)=CC(O)=C31 |
InChi Key | QUQPHWDTPGMPEX-QJBIFVCTSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Transportation | Not dangerous goods |
References | (1) E. Meiyanto, et al., Asian Pac. J. Cancer Prev. 13, 427 (2012), (2) H. Parhiz, et al., Phytother. Res. 29, 323 (2015) (Review), (3) A. Roohbakhsh, et al., Life Sci. 124, 64 (2015) (Review), (4) M. Iranshahi, et al., Life Sci. 137, 125 (2015) (Review), (5) A. Ahmadi & A. Shadboorestan, Nutr. Cancer 68, 29 (2016) (Review), (6) A. Ahmadi, et al., Curr. Med. Chem. 22, 3462 (2015) (Review), (7) S. Tejada, et al., Curr. Med. Chem. 25, 4929 (2018) (Review), (8) M. Hajialyani, et al., Molecules 24, E648 (2019) (Review) |
Quantity | 25 g, 100 g, Bulk |