Available from stock

Dibucaine hydrochloride

SKU: C0693

Category: API's & Intermediates

Synonyms: Cinchocaine hydrochloride , 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride; 61-12-1
CAS-Number: C₂₀H₂₉N₃O₂ · HCl
Molecular Formula: 379.92
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥99% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: water (50mg/ml), DMSO (50mg/ml), ethanol (50mg/ml)
Melting Point: 99-101 °C (lit.)

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at -20°C.

Hazard statements: H302-H318
Precautionary statements: P280-P305 + P351 + P338
GHS Symbol: GHS05+GHS07
Signal word: Danger
Transportation: Not dangerous goods

Description: Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.
Smiles: O=C(NCCN(CC)CC)C1=CC(OCCCC)=NC2=CC=CC=C21.Cl
InChi Key: IVHBBMHQKZBJEU-UHFFFAOYSA-N
References: (1) G.R. Padmanabhan, et al., Anal. Profiles Drug Subs. 12, 105 (1983) , (2) A Seelig, Biochim. Biophys. Acta 899, 196 (1987) , (3) E. Garcia-Martin & C. Gutierrez-Merino, J. Neurochem. 54, 1238 (1990) , (4) B.K. Stringer & H.J. Harmon, Biochem. Pharmacol. 40, 1077 (1990) , (5) A. Oda, et al., Am. J. Physiol. 269, C118 (1995) , (6) Y. Kuroda, et al., Biophys. J. 71, 1191 (1996) , (7) M. Kim, et al., Exp. Cell Res. 231, 235 (1997) , (8) M. Kansha, et al., Anesthesiology 91, 1798 (1999) , (9) K. Arita, et al., Biochem. Pharmacol. 60, 905 (2000) , (10) T. Souto-Padron, et al., Parasitol. Res. 99, 317 (2006) , (11) W. Zhang, et al., Int. J. Mol. Sci. 12, 2125 (2011) , (12) H.A. Douglas, et al., J. Neurophysiol. 105, 1482 (2011) , (13) R. Ulferts, et al., Antimicrob. Agents Chemother. 60, 2627 (2016)

Dibucaine is a long-acting local anesthetic. Potent Na+ channel blocker. It blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Induces apoptosis through calpain, cytochrome oxidase etc, and shows antiviral and antiparasitic activity.

SKU: C0693 Category: API's & Intermediates

Additional information

Additional information

Synonyms	Cinchocaine hydrochloride, 2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
Purity	≥99% (HPLC)
Appearance	White to off-white powder
CAS-Number	61-12-1
Molecular Formula	C20H29N3O2 · HCl
Molecular Weight	379.92
Identity	1H-NMR
Solvents	water (50mg/ml), DMSO (50mg/ml), ethanol (50mg/ml)
Melting Point	99-101 °C (lit.)
Smiles	O=C(NCCN(CC)CC)C1=CC(OCCCC)=NC2=CC=CC=C21.Cl
InChi Key	IVHBBMHQKZBJEU-UHFFFAOYSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at -20°C.
Hazard statements	H302-H318
Precautionary statements	P280-P305 + P351 + P338
GHS Symbol	GHS05+GHS07
Signal word	Danger
Transportation	Not dangerous goods
References	(1) G.R. Padmanabhan, et al., Anal. Profiles Drug Subs. 12, 105 (1983), (2) A Seelig, Biochim. Biophys. Acta 899, 196 (1987), (3) E. Garcia-Martin & C. Gutierrez-Merino, J. Neurochem. 54, 1238 (1990), (4) B.K. Stringer & H.J. Harmon, Biochem. Pharmacol. 40, 1077 (1990), (5) A. Oda, et al., Am. J. Physiol. 269, C118 (1995), (6) Y. Kuroda, et al., Biophys. J. 71, 1191 (1996), (7) M. Kim, et al., Exp. Cell Res. 231, 235 (1997), (8) M. Kansha, et al., Anesthesiology 91, 1798 (1999), (9) K. Arita, et al., Biochem. Pharmacol. 60, 905 (2000), (10) T. Souto-Padron, et al., Parasitol. Res. 99, 317 (2006), (11) W. Zhang, et al., Int. J. Mol. Sci. 12, 2125 (2011), (12) H.A. Douglas, et al., J. Neurophysiol. 105, 1482 (2011), (13) R. Ulferts, et al., Antimicrob. Agents Chemother. 60, 2627 (2016)
Quantity	1 g, 5 g, 25 g, Bulk