Available from stock

(-)-Huperzine A

SKU: H0208

Category: Phytochemicals

Synonyms: Hup A , (-)-Selagine , Kimpukan A; 102518-79-6
CAS-Number: C₁₅H₁₈N₂O
Molecular Formula: 242.32
Molecular Weight

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Data
Handling
Safety Information
Details

Specifications

Purity: ≥98% (HPLC)
Appearance: White to off-white powder
Identity: 1H-NMR

Properties

Solvents: DMSO (20 mg/ml), methanol (1 mg/ml)
Optical Activity: [α]/D -153±5°, c = 0.5 in methanol

Shipping: AMBIENT
Short Term Storage: +4°C
Long Term Storage: +4°C
Handling Advice: Protect from light and moisture.
Use / Stability: Stable for at least 2 years after receipt when stored at +4°C.

Hazard statements: H300
GHS Symbol: GHS06
Signal word: Danger
RIDADR: UN1544PSN1
Transportation: Packing Group II

Description: Huperzine A is a natural sesquiterpene alkaloid. It showns neuroprotective activity. It is a potent acetylcholinesterase (AChE) inhibitor and displays oral AChE inhibitory activity in animals. Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer’s disease. It has been shown to reduce neuronal cell death caused by glutamate and to have anti-inflammatory effects. It also has been shown to be an antagonist of NMDA receptor in cerebral cortex. It has been shown to ameliorate cognitive deficits.
Smiles: C/C=C1[C@@H]2CC3=C(C=CC(N3)=O)[C@@]/1(N)CC(C)=C2
InChi Key: ZRJBHWIHUMBLCN-ZUZCIYMTSA-N
References: (1) S.J. Geib, et al., Acta Crystallogr. C. 47, 824 (1991) , (1) H.S. Ved, et al., Neuroreport 8, 963 (1997) , (1) J.M. Zhang & G.Y. Hu, Neuroscience 105, 663 (2001) , (1) R.K. Gordon, et al., J. Appl. Toxicol. 21, S47 (2001) , (1) J. Zhou & X.C. Tang, FEBS Lett. 526, 21 (2002) , (1) R. Wang & X.C. Tang, Neurosignals 14, 71 (2005) (Review) , (1) H.Y. Zhang X.C. Tang, Trends Pharmacol. Sci. 27, 619 (2006) (Review) , (1) Z.F. Wang, et al., J. Neurochem. 106, 1594 (2008) , (1) X.Y. Mao, et al., Int. J. Mol. Sci. 15, 7667 (2014) , (1) H.Y. Zhang, et al., Cell Mol. Neurobiol. 28, 173 (2008) (Review) , (1) U. Damar, et al., Expert Rev. Neurother. 16, 671 (2016) (Review)
InChi: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1

Huperzine A is a natural sesquiterpene alkaloid. It showns neuroprotective activity. It is a potent acetylcholinesterase (AChE) inhibitor and displays oral AChE inhibitory activity in animals. Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer’s disease. It has been shown to reduce neuronal cell death caused by glutamate and to have anti-inflammatory effects. It also has been shown to be an antagonist of NMDA receptor in cerebral cortex. It has been shown to ameliorate cognitive deficits.

SKU: H0208 Category: Phytochemicals

Additional information

Additional information

Synonyms	Hup A, (-)-Selagine, Kimpukan A
Purity	≥98% (HPLC)
Appearance	White to off-white powder
CAS-Number	102518-79-6
Molecular Formula	C15H18N2O
Molecular Weight	242.32
Identity	1H-NMR
Solvents	DMSO (20 mg/ml), methanol (1 mg/ml)
Optical Activity	[α]/D -153±5°, c = 0.5 in methanol
Smiles	C/C=C1[C@@H]2CC3=C(C=CC(N3)=O)[C@@]/1(N)CC(C)=C2
InChi Key	ZRJBHWIHUMBLCN-ZUZCIYMTSA-N
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	+4°C
Handling Advice	Protect from light and moisture.
Use / Stability	Stable for at least 2 years after receipt when stored at +4°C.
Hazard statements	H300
GHS Symbol	GHS06
Signal word	Danger
RIDADR	UN1544PSN1
Transportation	Packing Group II
References	(1) S.J. Geib, et al., Acta Crystallogr. C. 47, 824 (1991), (1) H.S. Ved, et al., Neuroreport 8, 963 (1997), (1) J.M. Zhang & G.Y. Hu, Neuroscience 105, 663 (2001), (1) R.K. Gordon, et al., J. Appl. Toxicol. 21, S47 (2001), (1) J. Zhou & X.C. Tang, FEBS Lett. 526, 21 (2002), (1) R. Wang & X.C. Tang, Neurosignals 14, 71 (2005) (Review), (1) H.Y. Zhang X.C. Tang, Trends Pharmacol. Sci. 27, 619 (2006) (Review), (1) Z.F. Wang, et al., J. Neurochem. 106, 1594 (2008), (1) X.Y. Mao, et al., Int. J. Mol. Sci. 15, 7667 (2014), (1) H.Y. Zhang, et al., Cell Mol. Neurobiol. 28, 173 (2008) (Review), (1) U. Damar, et al., Expert Rev. Neurother. 16, 671 (2016) (Review)
InChi	InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1
Quantity	25 mg, Bulk