Specifications
- Purity
- ≥98% (HPLC)
- Appearance
- White to off-white powder
- Identity
- 1H-NMR
Properties
- Solvents
- DMSO (20 mg/ml), methanol (1 mg/ml)
- Optical Activity
- [α]/D -153±5°, c = 0.5 in methanol
Category: Phytochemicals
Huperzine A is a natural sesquiterpene alkaloid. It showns neuroprotective activity. It is a potent acetylcholinesterase (AChE) inhibitor and displays oral AChE inhibitory activity in animals. Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer’s disease. It has been shown to reduce neuronal cell death caused by glutamate and to have anti-inflammatory effects. It also has been shown to be an antagonist of NMDA receptor in cerebral cortex. It has been shown to ameliorate cognitive deficits.
Synonyms | Hup A, (-)-Selagine, Kimpukan A |
---|---|
Purity | ≥98% (HPLC) |
Appearance | White to off-white powder |
CAS-Number | 102518-79-6 |
Molecular Formula | C15H18N2O |
Molecular Weight | 242.32 |
Identity | 1H-NMR |
Solvents | DMSO (20 mg/ml), methanol (1 mg/ml) |
Optical Activity | [α]/D -153±5°, c = 0.5 in methanol |
Smiles | C/C=C1[C@@H]2CC3=C(C=CC(N3)=O)[C@@]/1(N)CC(C)=C2 |
InChi Key | ZRJBHWIHUMBLCN-ZUZCIYMTSA-N |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use / Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Hazard statements | H300 |
GHS Symbol | GHS06 |
Signal word | Danger |
RIDADR | UN1544PSN1 |
Transportation | Packing Group II |
References | (1) S.J. Geib, et al., Acta Crystallogr. C. 47, 824 (1991), (1) H.S. Ved, et al., Neuroreport 8, 963 (1997), (1) J.M. Zhang & G.Y. Hu, Neuroscience 105, 663 (2001), (1) R.K. Gordon, et al., J. Appl. Toxicol. 21, S47 (2001), (1) J. Zhou & X.C. Tang, FEBS Lett. 526, 21 (2002), (1) R. Wang & X.C. Tang, Neurosignals 14, 71 (2005) (Review), (1) H.Y. Zhang X.C. Tang, Trends Pharmacol. Sci. 27, 619 (2006) (Review), (1) Z.F. Wang, et al., J. Neurochem. 106, 1594 (2008), (1) X.Y. Mao, et al., Int. J. Mol. Sci. 15, 7667 (2014), (1) H.Y. Zhang, et al., Cell Mol. Neurobiol. 28, 173 (2008) (Review), (1) U. Damar, et al., Expert Rev. Neurother. 16, 671 (2016) (Review) |
InChi | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1 |
Quantity | 25 mg, Bulk |