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    Paeoniflorin

    Available from stock

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      Paeoniflorin

      SKU
      P0260

      Category: Carbohydrates

      Synonyms
      NSC 178886
      23180-57-6
      CAS-Number
      C23H28O11
      Molecular Formula
      480.46
      Molecular Weight

      For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

      • Product Data
      • Handling
      • Safety Information
      • Details

      Specifications

      Purity
      ≥98% (HPLC)
      Appearance
      White to off-white powder
      Identity
      1H-NMR

      Properties

      Solvents
      DMSO, DMF, ethanol (all 20mg/ml), water (10mg/ml).
      Shipping
      AMBIENT
      Short Term Storage
      RT
      Long Term Storage
      RT
      Handling Advice
      Protect from light and moisture.
      Use / Stability
      Stable for at least 2 years after receipt when stored at RT.
      Transportation
      Not dangerous goods
      Description
      Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor (LXR) agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects. In addition, this potential anticancer agent, has ben described as a EP2 receptor agonists, a heat-shock protein (HSP)-inducing compound, by activation of HSF1, or by interacting with NOTCH1 or mTOR/HIF-1 signaling pathways.
      Smiles
      O[C@]12O[C@@]3([H])O[C@](C2)(C)[C@@]4([C@@]3(COC(C5=CC=CC=C5)=O)[C@@]1([H])C4)O[C@@H]([C@@H]([C@H]6O)O)O[C@H](CO)[C@H]6O
      InChi Key
      YKRGDOXKVOZESV-WRJNSLSBSA-N
      References
      (1) J. Yamahara, et al., J. Pharmacobiodyn. 5, 921 (1982) , (2) T. Takeuchi, et al., Amer. J. Chin. Med. 19, 73 (1991) , (3) F.L. Hsu, et al., Planta Med. 63, 323 (1997) , (4) C.W. Lai, et al., Life Sci. 62, 1591 (1998) , (5) H.O. Yang, et al., Fitoterapia 75, 45 (2004) , (6) D. Yan, et al., Cell Stress Chaperones 9, 378 (2004) , (7) D.Z. Liu, et al., Br. J. Pharmacol. 146, 604 (2005) , (8) H.Q. Liu, et al., Br. J. Pharmacol. 148, 314 (2006) , (9) J.Y. Hung, et al., Clin. Exp. Pharmacol. Physiol. 35, 141 (2008) , (10) H. Wu, et al., Biomed. Pharmacother. 62, 659 (2008) , (11) J. Fu, et al., Comp. Med. 59, 557 (2009) , (12) J. Huang, et al., Int. Immunopharmacol. 10, 1279 (2010) , (13) Q.Q. Mao, et al., Phytother. Res. 25, 681 (2011) , (14) S. Hu, et al., Anticancer Drugs 24, 140 (2013) , (15) R.B. Guo, et al., PLoS One 7, e49701 (2012) , (16) H.R. Lin, J. Asian Nat. Prod. Res. 15, 35 (2013) , (17) F.M. Qiu, et al., Neurosci. Lett. 541, 209 (2013) , (18) W. Li, et al., Mol. Med. Rep. 12, 2735 (2015) , (19) F. Han, et al., Cell Biosci. 6, 37 (2016) , (20) S. Wang & W. Liu, Mol. Med. Rep. 14, 2143 (2016) , (21) R. Lu, et al., Biomed. Pharmacother. 96, 137 (2017) , (22) J. Zhang, et al., Mol. Med. Rep. 17, 1321 (2018) , (23) H. Wang, et al., J. Cell Physiol. (Epub ahead of print) (2018) , (24) L.B. Jin, et al., Mol. Med. Rep. 17, 5095 (2018)

      Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor (LXR) agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects. In addition, this potential anticancer agent, has ben described as a EP2 receptor agonists, a heat-shock protein (HSP)-inducing compound, by activation of HSF1, or by interacting with NOTCH1 or mTOR/HIF-1 signaling pathways.

      SKU: P0260 Category: Carbohydrates
      • Additional information

      Additional information

      Synonyms

      NSC 178886

      Purity

      ≥98% (HPLC)

      Appearance

      White to off-white powder

      CAS-Number

      23180-57-6

      Molecular Formula

      C23H28O11

      Molecular Weight

      480.46

      Identity

      1H-NMR

      Solvents

      DMSO, DMF, ethanol (all 20mg/ml), water (10mg/ml).

      Smiles

      O[C@]12O[C@@]3([H])O[C@](C2)(C)[C@@]4([C@@]3(COC(C5=CC=CC=C5)=O)[C@@]1([H])C4)O[C@@H]([C@@H]([C@H]6O)O)O[C@H](CO)[C@H]6O

      InChi Key

      YKRGDOXKVOZESV-WRJNSLSBSA-N

      Shipping

      AMBIENT

      Short Term Storage

      RT

      Long Term Storage

      RT

      Handling Advice

      Protect from light and moisture.

      Use / Stability

      Stable for at least 2 years after receipt when stored at RT.

      Transportation

      Not dangerous goods

      References

      (1) J. Yamahara, et al., J. Pharmacobiodyn. 5, 921 (1982), (2) T. Takeuchi, et al., Amer. J. Chin. Med. 19, 73 (1991), (3) F.L. Hsu, et al., Planta Med. 63, 323 (1997), (4) C.W. Lai, et al., Life Sci. 62, 1591 (1998), (5) H.O. Yang, et al., Fitoterapia 75, 45 (2004), (6) D. Yan, et al., Cell Stress Chaperones 9, 378 (2004), (7) D.Z. Liu, et al., Br. J. Pharmacol. 146, 604 (2005), (8) H.Q. Liu, et al., Br. J. Pharmacol. 148, 314 (2006), (9) J.Y. Hung, et al., Clin. Exp. Pharmacol. Physiol. 35, 141 (2008), (10) H. Wu, et al., Biomed. Pharmacother. 62, 659 (2008), (11) J. Fu, et al., Comp. Med. 59, 557 (2009), (12) J. Huang, et al., Int. Immunopharmacol. 10, 1279 (2010), (13) Q.Q. Mao, et al., Phytother. Res. 25, 681 (2011), (14) S. Hu, et al., Anticancer Drugs 24, 140 (2013), (15) R.B. Guo, et al., PLoS One 7, e49701 (2012), (16) H.R. Lin, J. Asian Nat. Prod. Res. 15, 35 (2013), (17) F.M. Qiu, et al., Neurosci. Lett. 541, 209 (2013), (18) W. Li, et al., Mol. Med. Rep. 12, 2735 (2015), (19) F. Han, et al., Cell Biosci. 6, 37 (2016), (20) S. Wang & W. Liu, Mol. Med. Rep. 14, 2143 (2016), (21) R. Lu, et al., Biomed. Pharmacother. 96, 137 (2017), (22) J. Zhang, et al., Mol. Med. Rep. 17, 1321 (2018), (23) H. Wang, et al., J. Cell Physiol. (Epub ahead of print) (2018), (24) L.B. Jin, et al., Mol. Med. Rep. 17, 5095 (2018)

      Quantity

      25 mg, 100 mg, 250 mg, Bulk

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